Adherence to ketoacids/essential amino acids-supplemented low protein diets and new indications for patients with chronic kidney disease

BMC Nephrology

Review

Vladimir Teplan¹  Liliana Garneata²  Wei Chen³  Joel D. Kopple⁴  Kamyar Kalantar-Zadeh⁵  SJ Hwang⁶  Jing Chen⁷  William E. Mitch⁸  Giorgina Piccoli⁹  Philippe Chauveau^1,10  Denis Fouque^1,11 

[1] Department Nephrol, Institute Clin Exp Med, Transpl Centre, Prague, Czech Republic;Department Nephrology and Internal Medicine, Dr Carol Davila Hospital of Nephrology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania;Department of Parenteral and Enteral Nutrition, Peking Union Medical College Hospital, Beijing, China;Division Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA;David Geffen School of Medicine at UCLA, UCLA Fielding School of Public Health, Los Angeles, CA, USA;Division Nephrology and Hypertension, University of California Irvine School of Medicine, Irvine, CA, USA;Deparment Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA;Division Nephrology, Kaohsiung Medical University Hospital, Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China;Nephrology Division, Baylor College of Medicine, Houston, TX, USA;SS Nephrology, ASOU San Luigi, Departmentt of Clinical and Biological Sciences, University of Torino, Turin, Italy;Service de Néphrologie, CHU de Bordeaux & Aurad-Aquitaine, Bordeaux, France;UCBL, Centre Hospitalier Lyon-Sud, University Lyon, Carmen, Cens, F-69622, Lyon, France;Department Nephrology, Centre Hospitalier Lyon Sud, Chemin du grand revoyet, 69495, Pierre Bénite, France;

关键词: Protein;    Ketoacid;    Keto-analog;    Low protein diet;    Kidney disease;    Wasting;    Dialysis;   

DOI  :  10.1186/s12882-016-0278-7

 received in 2016-01-08, accepted in 2016-06-14,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundLow protein diets (LPD) have long been prescribed to chronic kidney disease patients with the goals of improving metabolic abnormalities and postpone the start of maintenance dialysis.MethodsWe reviewed the recent literature addressing low protein diets supplemented with ketoacids/essential aminoacids prescribed during chronic kidney disease and their effects on metabolic, nutritional and renal parameters since 2013.ResultsWe show new information on how to improve adherence to these diets, on metabolic improvement and delay of the dialysis needs, and preliminary data in chronic kidney disease associated pregnancy. In addition, data on incremental dialysis have been reviewed, as well as potential strategies to reverse protein energy wasting in patients undergoing maintenance dialysis.ConclusionThese recent data help to better identify the use of low protein diets supplemented with ketoacids/essential aminoacids during chronic kidney disease.

【 授权许可】

CC BY   
© The Author(s). 2016