Prevalence and drug resistance of mycobacteria in Turkish cystic fibrosis patients

Annals of Clinical Microbiology and Antimicrobials

Research

Dilek Satana¹  Zayre Erturan¹  Gonca Erkose-Genc¹  Meltem Uzun¹  Nermin Guler²  Zeynep Tamay² 

[1] Department of Medical Microbiology, Istanbul Faculty of Medicine, Istanbul University, 34093, Istanbul, Turkey;Department of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, 34093, Istanbul, Turkey;

关键词: Mycobacteria;    Nontuberculous mycobacteria;    Mycobacterium tuberculosis;    Cystic fibrosis;    Drug resistance;   

DOI  :  10.1186/1476-0711-13-28

 received in 2014-02-10, accepted in 2014-06-05,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundIsolation of mycobacteria in cystic fibrosis (CF) patients is increasingly being reported. Because of having long term antimicrobial treatment, CF patients are at risk of pulmonary infection with especially resistant nontuberculous mycobacteria (NTM) strains. The aim of the present study is to determine the prevalence of mycobacterium spp. and antimicrobial susceptibility in Turkish CF patients.MethodsDuring a 5.5 year study period, 376 sputa from 130 CF patients were analyzed. Antimycobacterial susceptibility testing was performed by the Bactec 460 TB System and the E test method.ResultsTotaly 28 (7.44%) Mycobacterium spp. were isolated from eight (6.15%) CF patients. Five isolates (17.9%) were identified as Mycobacterium tuberculosis complex (MTBC), 14 (50%) as Mycobacterium abscessus and nine (32.1%) as Mycobacterium lentiflavum. All MTBC isolates were found to be susceptible to streptomycin, isoniazid, rifampicin, and ethambutol. Resistance to some antibiotics was detected in some NTM strains. These are the first data about the prevalence of mycobacteria in CF patients from Turkey.ConclusionsIn pediatric CF patients, specific mycobacterial analysis of sputum specimens and susceptibility testing should be performed for allowing early detection, identification and the possibility of eradication of these bacteria.

【 授权许可】

Unknown   
© Satana et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.