The role of hepatic fat accumulation in pathogenesis of non-alcoholic fatty liver disease (NAFLD)

Lipids in Health and Disease

Review

Shen Qu¹  Qing Liu²  Stig Bengmark³ 

[1] Deaprtment of Endocrinology, Tenth People's Hospital, Tongji University, 200072, Shanghai, China;Deaprtment of Endocrinology, Tenth People's Hospital, Tongji University, 200072, Shanghai, China;Beijing You An Hospital, 100006, Beijing, China;Departments of Hepatology and Surgery, University College London, 69 - 75 Chenies Mews, WC1E 6HX, London, UK;

关键词: Insulin Resistance;    NASH;    Hepatic Steatosis;    Nonalcoholic Fatty Liver Disease;    Hepatic Insulin Resistance;   

DOI  :  10.1186/1476-511X-9-42

 received in 2010-02-23, accepted in 2010-04-28,  发布年份 2010

来源: Springer

【 摘 要 】

Nonalcoholic fatty liver disease is increasingly regarded as a hepatic manifestation of metabolic syndrome, and the severity of nonalcoholic fatty liver disease seems to increase in parallel with other features of metabolic syndrome. Excess lipid accumulation in the liver cells is not only a mediator of Metabolic Syndrome and indicator of a lipid overload but also accompanied by a range of histological alterations varying from 'simple' steatosis to nonalcoholic steatohepatitis, with time progressing to manifest cirrhosis. Hepatocellular carcinoma may also occur in nonalcoholic steatohepatitis -related cirrhosis with a mortality rate similar to or worse than for cirrhosis associated with hepatitis C. This review summarizes the knowledge about the causal relationship between hepatic fat accumulation, insulin resistance, liver damage and the etiological role of hepatic fat accumulation in pathogenesis of extra- and intra-hepatic manifestations. Special emphasis is given suggestions of new targets treatment and prevention of nonalcoholic fatty liver disease.

【 授权许可】

Unknown   
© Liu et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.