Evaluation of various biomarkers for kidney monitoring during canine leishmaniosis treatment

BMC Veterinary Research

Research Article

Josep Pastor¹  Luis Pardo-Marín²  José Joaquín Cerón²  Silvia Martínez-Subiela²  Juan Diego Garcia-Martinez²  Asta Tvarijonaviciute³  Sergi Segarra⁴ 

[1] Departament de Medicina i Cirurgia Animals, Universitat Autònoma de Barcelona, Bellaterra, 08193, Barcelona, Spain;Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Veterinary School, Campus of Excellence Mare Nostrum, University of Murcia, 30100, Espinardo, Murcia, Spain;Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Veterinary School, Campus of Excellence Mare Nostrum, University of Murcia, 30100, Espinardo, Murcia, Spain;Departament de Medicina i Cirurgia Animals, Universitat Autònoma de Barcelona, Bellaterra, 08193, Barcelona, Spain;R&D Bioiberica SA, Pça. Francesc Macià 7, 08029, Barcelona, Spain;

关键词: Urine;    Kidney;    Immunoglobulin G (IgG);    UPC;    Creatinine;    Symmetric dimethylarginine (SDMA);    Gamma glutamyl-transpeptidase (GGT);    Retinol-binding protein (RBP);   

DOI  :  10.1186/s12917-017-0956-0

 received in 2016-10-27, accepted in 2017-01-17,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe objective of this study was to evaluate and compare the evolution of the profile currently recommended by the International Renal Interest Society (IRIS) (sCr, UPC and sSDMA) with a panel of other different kidney biomarkers during treatment for canine leishmaniosis. This panel included three urinary glomerular biomarkers (uIgG, uCRP and uferritin) and three urinary tubular biomarkers (uGGT, uNAG and uRBP).These biomarkers were measured in two groups of dogs with canine leishmaniosis at IRIS stage I. Group 1: dogs showing proteinuria (UPC > 0.5) before treatment which did not decrease after treatment; Group 2: dogs showing proteinuria before treatment which decreased after treatment.ResultsGroup 1 showed no significant changes in any biomarker after treatment. In group 2, among the biomarkers recommended by the IRIS, only UPC showed a significant decrease after treatment. However all biomarkers of glomerular damage showed a significant decrease after treatment, with uIgG/Cr and uCRP/Cr showing the greater decreases. In addition uRBP/Cr and uNAG/Cr showed significant decreases after treatment.ConclusionsIn dogs with leishmaniosis at IRIS stage I that reduced UPC after treatment, there were no significant changes in serum creatinine and sSDMA. However, all the urine biomarkers evaluated with exception of uGGT showed a significant decrease. These decreases were more evident in those markers related with glomerular function, being uIgG/Cr the biomarker more associated with UPC. Further studies involving a larger number of animals and histological analysis of the kidney would be recommended to confirm these findings and evaluate the routine practical use of these urine biomarkers in canine leishmaniosis.

【 授权许可】

CC BY   
© The Author(s). 2017