Expression TGM2 and BNIP3 have prognostic significance in laryngeal cancer patients receiving surgery and postoperative radiotherapy: A retrospective study

Journal of Translational Medicine

Research

Li-Bing Guo¹  Ting Jin²  Qiu-Li Li³  Wen-Kuan Chen³  Rui Sun⁴  Nan Ge⁴  Hui Lin⁴  Wei-Han Hu⁴  Xiu-Yu Cai⁴  Huan-Xin Lin⁴ 

[1] Department of Oncology, Guangdong Second Provincial People's Hospital, 510060, Guangzhou, Guangdong, People's Republic of China;Department of Radiation Oncology, Zhejiang Cancer Hospital, 310022, Hangzhou, Zhejiang, People's Republic of China;State Key Laboratory of Oncology in South China, Sun Yat -sen University Cancer center, 510060, Guangzhou, Guangdong, People's Republic of China;Department of Head and Neck Surgery, Sun Yat -sen University Cancer Center, 510060, Guangzhou, Guangdong, People's Republic of China;State Key Laboratory of Oncology in South China, Sun Yat -sen University Cancer center, 510060, Guangzhou, Guangdong, People's Republic of China;Department of Radiation Oncology, Sun Yat -sen University Cancer center, 510060, Guangzhou, Guangdong, People's Republic of China;

关键词: TGM2;    BNIP3;    Postoperative radiotherapy;    Laryngeal cancer;    Prognosis;   

DOI  :  10.1186/1479-5876-10-64

 received in 2011-10-10, accepted in 2012-03-30,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThis study was designed to determine the pattern and correlation between expression of the HIF-1α transcriptional targets TGM2 and BNIP3 in laryngeal cancer, and investigate the association of BNIP3 and TGM2 with clinical outcome in laryngeal squamous cell carcinoma (SCC) patients receiving postoperative radiotherapy.MethodsImmunostaining with antibodies specific to BNIP3 and TGM2 was performed in formalin-fixed, paraffin-embedded specimens from 148 laryngeal SCC patients. BNIP3 and TGM2 expression was scored as high or low, based on the number of tumor cells stained and the staining intensity. All patients received postoperative radiotherapy. Patient follow up and clinicopathological data were compared using the Chi-squared test, univariate and multivariate analyses, and survival curves were generated using the Kaplan-Meier method and log-rank test.ResultsThe 3, 5 and 10-year overall survival rates (OS) for all patients were 77.7%, 71.6%, 56.4%, respectively. Primary tumor site, T stage, overall stage, lymph-node metastasis, BNIP3 expression and TGM2 expression were significant prognostic factors for OS in univariate analysis. Negative cervical lymph nodes, high BNIP3 expression and low TGM2 expression were independent prognostic factors of improved OS in multivariate analysis. BNIP3 expression correlates with TGM2 expression in laryngeal SCC (P = 0.012).ConclusionsThis study indicates that lymph-node metastasis, BNIP3 expression and TGM2 expression are independent prognostic factors in laryngeal SCC patients receiving postoperative radiotherapy. Further studies are required to investigate how BNIP3 and/or TGM2 influence the prognosis of laryngeal SCC patients treated with postoperative radiotherapy, and to determine how TGM2 and BNIP3 expression are regulated.

【 授权许可】

Unknown   
© Jin et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.