Outcome benefit of abdominal paracentesis drainage for severe acute pancreatitis patients with serum triglyceride elevation by decreasing serum lipid metabolites

Lipids in Health and Disease

Research

Hong-Yin Liang¹  Li-Jun Tang¹  Long Cheng¹  Tao Wang¹  Zhu-Lin Luo¹  Kui-Ying Wang¹  Sun-Hong Yu¹  Tao Chen¹  Lin Ning¹  Wei-Hui Liu¹  Hong-Tao Yan¹  Jing Zhou²  Zhu Huang² 

[1] General Surgery Center of PLA, Chengdu Military General Hospital, 610083, Chengdu, Sichuan Province, China;Postgraduate Department, Third Military Medical University, Chongqing, China;General Surgery Center of PLA, Chengdu Military General Hospital, 610083, Chengdu, Sichuan Province, China;

关键词: Severe acute pancreatitis;    Abdominal paracentesis drainage;    Free fatty acid;   

DOI  :  10.1186/s12944-016-0276-6

 received in 2016-05-06, accepted in 2016-06-15,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundOur previous reports demonstrated that abdominal paracentesis drainage (APD) exerts a beneficial effect on severe acute pancreatitis (SAP) patients. However, the underlying mechanisms for this effectiveness are not well understood.MethodsA retrospective cohort of 132 consecutive non-hypertriglyceridemia (HTG)-induced SAP patients with triglyceride (TG) elevation and pancreatitis-associated ascitic fluid (PAAF) was recruited from May 2010 to May 2015 and included in this study. The patients were divided into two groups: the APD group (n = 68) and the non-APD group (n = 64). The monitored parameters mainly included mortality, hospital stay, the incidence of further intervention, levels of serum lipid metabolites and inflammatory factors, parameters related to organ failure and infections, and severity scores.ResultsThe demographic data and severity scores were comparable between the two groups. Compared with the non-APD group, the primary outcomes (including mortality, hospital stay and the incidence of percutaneous catheter drainage) in the APD group were improved. The serum levels of lipid metabolites were significantly lower in the APD group after 2 weeks of treatment than in the non-APD group. Logistic regression analysis indicated that the decreased extent of free fatty acid (FFA)(odds ratio, 1.435; P = 0.015) was a predictor of clinical improvement after 2 weeks of treatment.ConclusionTreatment with APD benefits non-HTG-induced SAP patients with serum TG elevation by decreasing serum levels of FFA.

【 授权许可】

CC BY   
© The Author(s). 2016