Characterization of outbreak response strategies and potential vaccine stockpile needs for the polio endgame

BMC Infectious Diseases

Research Article

Mark A. Pallansch¹  Steven G. F. Wassilak²  Stephen L. Cochi²  Kimberly M. Thompson³  Radboud J. Duintjer Tebbens³ 

[1] Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA;Global Immunization Division, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, USA;Kid Risk, Inc., 10524 Moss Park Rd., Ste. 204-364, 32832, Orlando, FL, USA;

关键词: Polio;    Eradication;    Risk management;    Vaccine;    Stockpile;   

DOI  :  10.1186/s12879-016-1465-7

 received in 2015-10-03, accepted in 2016-03-11,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundFollowing successful eradication of wild polioviruses and planned globally-coordinated cessation of oral poliovirus vaccine (OPV), national and global health leaders may need to respond to outbreaks from reintroduced live polioviruses, particularly vaccine-derived polioviruses (VDPVs). Preparing outbreak response plans and assessing potential vaccine needs from an emergency stockpile require consideration of the different national risks and conditions as they change with time after OPV cessation.MethodsWe used an integrated global model to consider several key issues related to managing poliovirus risks and outbreak response, including the time interval during which monovalent OPV (mOPV) can be safely used following homotypic OPV cessation; the timing, quality, and quantity of rounds required to stop transmission; vaccine stockpile needs; and the impacts of vaccine choices and surveillance quality. We compare the base case scenario that assumes aggressive outbreak response and sufficient mOPV available from the stockpile for all outbreaks that occur in the model, with various scenarios that change the outbreak response strategies.ResultsOutbreak response after OPV cessation will require careful management, with some circumstances expected to require more and/or higher quality rounds to stop transmission than others. For outbreaks involving serotype 2, using trivalent OPV instead of mOPV2 following cessation of OPV serotype 2 but before cessation of OPV serotypes 1 and 3 would represent a good option if logistically feasible. Using mOPV for outbreak response can start new outbreaks if exported outside the outbreak population into populations with decreasing population immunity to transmission after OPV cessation, but failure to contain outbreaks resulting in exportation of the outbreak poliovirus may represent a greater risk. The possibility of mOPV use generating new long-term poliovirus excretors represents a real concern. Using the base case outbreak response assumptions, we expect over 25 % probability of a shortage of stockpiled filled mOPV vaccine, which could jeopardize the achievement of global polio eradication. For the long term, responding to any poliovirus reintroductions may require a global IPV stockpile. Despite the risks, our model suggests that good risk management and response strategies can successfully control most potential outbreaks after OPV cessation.ConclusionsHealth leaders should carefully consider the numerous outbreak response choices that affect the probability of successfully managing poliovirus risks after OPV cessation.

【 授权许可】

CC BY   
© Duintjer Tebbens et al. 2016