Latent tuberculosis in children and youth with type 1 diabetes mellitus in Dar es Salaam, Tanzania: a cross section survey

BMC Infectious Diseases

Research

Kenneth Byashalira¹  Blandina T Mmbaga²  Edna S. Majaliwa³  Sayoki G Mfinanga⁴  Evance Godfrey⁵  Kandi Muze⁵  Kaushik Ramaiya⁶ 

[1]Kilimanjaro Christian Medical University College, Box 2240, Moshi, Kilimanjaro, United Republic of Tanzania

[2]Kibong’oto Infectious Diseases Hospital, Sanya Juu, Siha, United Republic of Tanzania

[3]Kilimanjaro Christian Medical University College, Box 2240, Moshi, Kilimanjaro, United Republic of Tanzania

[4]Kilimanjaro Clinical Research Institute, Moshi, United Republic of Tanzania

[5]Kilimanjaro Christian Medical University College, Box 2240, Moshi, Kilimanjaro, United Republic of Tanzania

[6]Muhimbili National Hospital, Box 65000, Dar es Salaam, United Republic of Tanzania

[7]Muhimbili Medical Research Centre, National Institute for Medical Research, Dar es Salaam, United Republic of Tanzania

[8]School of Public Health, Department of Epidemiology and Statistics, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania

[9]Alliance for Africa Research and Innovation, Dar es Salaam, United Republic of Tanzania

[10]Muhimbili National Hospital, Box 65000, Dar es Salaam, United Republic of Tanzania

[11]Shree Hindu Mandal Hospital, Dar es Salaam, United Republic of Tanzania

关键词: Diabetes;    T1DM;    Glycaemic;    Latent tuberculosis;    Children;    Youth;    QuantiFERON;   

DOI  :  10.1186/s12879-023-08753-4

 received in 2023-03-10, accepted in 2023-10-25,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundData for latent tuberculosis in patients with type 1 Diabetes in Africa is limited. We assessed the prevalence of latent tuberculosis in youth and children with type 1 Diabetes in Dar es Salaam –Tanzania.MethodsOur cross-sectional study recruited children and youth with T1DM by stage of puberty, glycaemic control, and age at diagnosis from January to December 2021 in Dar es Salaam. Participants were screened for the presence of latent Tuberculosis using the QuantiFERON test. A positive test was considered to have latent TB.ResultsOf the 281 participants, the mean age was 19 (± 6) years, 51.2% were female, and 80.8% had either a primary or secondary level of education at baseline. The prevalence of latent TB was 14.9% and was slightly higher in females (52.4%) than in males. This difference, however, was insignificant (p > 0.05). On the other hand, the proportion of latent TB was significantly higher in uncontrolled HbA1c levels (76.2%) than in those with controlled HbA1c (23.8%) [p = 0.046]. Duration of diabetes and age at diagnosis did not affect the occurrence of latent Tuberculosis [p > 0.05]. Meanwhile, in the regression model, participants with latent TB were more likely to have uncontrolled HbA1c. [p = 0.045]ConclusionsDespite the methodological limitations, this survey highlights the high prevalence of latent TB among children and youth with diabetes; shouting for better control. These results clearly show the need to screen for Tuberculosis in children and youth with diabetes and start them on prevention as per protocol, especially in tuberculosis-endemic areas like Tanzania.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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