Serum uric acid level and its association with metabolic syndrome and carotid atherosclerosis in patients with type 2 diabetes

Cardiovascular Diabetology

Original Investigation

Shen Qu¹  Zhen Yang¹  Lili Chen²  Renming Hu²  Xiaoming Tao²  Weiwei Zhang²  Ying Huang²  Zhaoyun Zhang²  Qin Li²  Jie Wen²  Bin Lu²  Min He²  Zi Ye² 

[1] Department of endocrinology, Shanghai tenth people's hospital, School of medicine, Tongji University, 301 Middle Yanchang Road, Shanghai, China;Institute of endocrinology and diabetology, Huashan hospital, Shanghai medical college, Fudan University, 12 Middle Wulumuqi Road, Shanghai, China;

关键词: uric acid;    metabolic syndrome;    intima-media thickness;    atherosclerosis;   

DOI  :  10.1186/1475-2840-10-72

 received in 2011-07-23, accepted in 2011-08-04,  发布年份 2011

来源: Springer

【 摘 要 】

ObjectiveWe aimed to investigate whether elevated serum uric acid concentrations are associated with higher risk of metabolic syndrome (MetS) and carotid atherosclerosis in patients with type 2 diabetes.MethodsWe conducted a population-based cross-sectional survey in Shanghai, with a total of 395 men and 631 women age 41 to 92 years. The carotid artery intima-media thickness (IMT) and carotid atherosclerotic plaques (PLQ) were measured by B-mode ultrasound. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans.ResultsUric acid levels were negatively associated with duration of diabetes, fasting plasma glucose, glycohemoglobin, eGFR, HDL-cholesterol (all P < 0.001) and positively with BMI, CRP, waist circumference, triglycerides, systolic blood pressure, ACR, HOMA-IR and IMT (all P < 0.05). In the highest quartile of uric acid levels, the risks were substantially higher for MetS [odds ratio 3.97, (95% confidence interval 2.58-6.13)] (P < 0.001 for trend) and PLQ [odds ratio 2.71 (95% confidence interval 1.62-4.47)] (p = 0.013 for trend) compared with that in the lowest quartile of uric acid levels after multiple adjustment. These associations remained significant after further adjustment for potential confounders.ConclusionsSerum uric acid level is associated with MetS and is an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes.

【 授权许可】

Unknown   
© Li et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.