Right ventricular volumes and function in thalassemia major patients in the absence of myocardial iron overload

Journal of Cardiovascular Magnetic Resonance

Research

Alicia Maceira¹  Francisco Alpendurada²  Winston Banya²  Taigang He²  Monica Deac²  Gillian C Smith³  John-Paul Carpenter³  Dudley J Pennell³  Paul Kirk³  John B Porter⁴  J Malcolm Walker⁴  Maciej Garbowski⁴  Farrukh Shah⁵ 

[1] Cardiac Imaging Unit, ERESA, Valencia, Spain;Cardiovascular MR Unit, Royal Brompton Hospital, London, London, UK;Cardiovascular MR Unit, Royal Brompton Hospital, London, London, UK;National Heart and Lung Institute, Imperial College London, London, UK;Department of Haematology, University College London, London, UK;Department of Haematology, Whittington Hospital, London, UK;

关键词: Right Ventricular;    Cardiovascular Magnetic Resonance;    Deferasirox;    Right Ventricular Function;    Right Ventricular Ejection Fraction;   

DOI  :  10.1186/1532-429X-12-24

 received in 2010-02-16, accepted in 2010-04-23,  发布年份 2010

来源: Springer

【 摘 要 】

AimWe aimed to define reference ranges for right ventricular (RV) volumes, ejection fraction (EF) in thalassemia major patients (TM) without myocardial iron overload.Methods and resultsRV volumes, EF and mass were measured in 80 TM patients who had no myocardial iron overload (myocardial T2* > 20 ms by cardiovascular magnetic resonance). All patients were receiving deferoxamine chelation and none had evidence of pulmonary hypertension or other cardiovascular comorbidity. Forty age and sex matched healthy non-anemic volunteers acted as controls. The mean RV EF was higher in TM patients than controls (males 66.2 ± 4.1% vs 61.6 ± 6%, p = 0.0009; females 66.3 ± 5.1% vs 62.6 ± 6.4%, p = 0.017), which yielded a raised lower threshold of normality for RV EF in TM patients (males 58.0% vs 50.0% and females 56.4% vs 50.1%). RV end-diastolic volume index was higher in male TM patients (mean 98.1 ± 17.3 mL vs 88.4 ± 11.2 mL/m2, p = 0.027), with a higher upper limit (132 vs 110 mL/m2) but this difference was of borderline significance for females (mean 86.5 ± 13.6 mL vs 80.3 ± 12.8 mL/m2, p = 0.09, with upper limit of 113 vs 105 mL/m2). The cardiac index was raised in TM patients (males 4.8 ± 1.0 L/min vs 3.4 ± 0.7 L/min, p < 0.0001; females 4.5 ± 0.8 L/min vs 3.2 ± 0.8 L/min, p < 0.0001). No differences in RV mass index were identified.ConclusionThe normal ranges for functional RV parameters in TM patients with no evidence of myocardial iron overload differ from healthy non-anemic controls. The new reference RV ranges are important for determining the functional effects of myocardial iron overload in TM patients.

【 授权许可】

Unknown   
© Carpenter et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.