期刊论文

【摘要】

There are many reasons to be interested in stem cells, one of the most prominent being their potential use in finding better drugs to treat human disease. This article focuses on how this may be implemented. Recent advances in the production of reprogrammed adult cells and their regulated differentiation to disease-relevant cells are presented, and diseases that have been modeled using these methods are discussed. Remaining difficulties are highlighted, as are new therapeutic insights that have emerged.

【授权许可】

CC BY
© Rubin and Haston; licensee BioMed Central Ltd. 2011

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BMC Biology
Stem cell biology and drug discovery
Review
Lee L Rubin¹ Kelly M Haston¹
[1] Dept of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, 02138, Cambridge, MA, USA;
关键词: Amyotrophic Lateral Sclerosis; Motor Neuron; Spinal Muscular Atrophy; iPSC; Stem Cell Biology;
DOI : 10.1186/1741-7007-9-42
received in 2011-04-27, accepted in 2011-06-07, 发布年份 2011
来源: Springer
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