Influence on therapeutic outcome of platelet count at diagnosis in patients with de novo non-APL acute myeloid leukemia

BMC Cancer

Research

Yujiao Zhang¹  Baoyi Yuan¹  Ling Jiang¹  Jieyu Ye¹  Xuejie Jiang¹  Fang Liu¹  Quan Wu¹  Yun Huang¹  Ping Yan¹  Yongshuai Jiang² 

[1] Department of Hematology, Nanfang Hospital, Southern Medical University, 510515, Guangzhou, Guangdong, China;School of Medicine, Zhengzhou University, 450001, Zhengzhou, China;

关键词: Acute Myeloid Leukemia;    Platelet count;    Therapeutic outcome;    Overall survival;    Relapse-free survival;   

DOI  :  10.1186/s12885-023-11543-5

 received in 2023-05-12, accepted in 2023-10-18,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundPlatelet (PLT) count at diagnosis plays an important role in cancer development and progression in solid tumors. However, it remains controversial whether PLT count at diagnosis influences therapeutic outcome in patients with non-acute promyelocytic leukemia (APL) acute myeloid leukemia (AML).MethodsThis study analyzed the relationship between PLT count at diagnosis and genetic mutations in a cohort of 330 newly diagnosed non-APL AML patients. The impact of PLT count on complete remission, minimal residual disease status and relapse-free survival (RFS) were evaluated after chemotherapy or allogeneic hematopoietic stem cell transplantation (allo-HSCT).ResultsOur studies showed that patients with DNMT3A mutations have a higher PLT count at diagnosis, while patients with CEBPA biallelic mutations or t(8;21)(q22; q22) translocation had lower PLT count at diagnosis. Furthermore, non-APL AML patients with high platelet count (> 65 × 109/L) at diagnosis had worse response to induction chemotherapy and RFS than those with low PLT count. In addition, allo-HSCT could not absolutely attenuated the negative impact of high PLT count on the survival of non-APL AML patients.ConclusionPLT count at diagnosis has a predictive value for therapeutic outcome for non-APL AML patients.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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