Quantification of myocardial perfusion using CMR with a radial data acquisition: comparison with a dual-bolus method

Journal of Cardiovascular Magnetic Resonance

Research

Nathan A Pack¹  Liyong Chen¹  Edward VR DiBella¹  Tae Ho Kim² 

[1] Utah Center for Advanced Imaging Research, Department of Radiology, 729 Arapeen Dr. University of Utah, 84108, Salt Lake City, Utah, USA;Utah Center for Advanced Imaging Research, Department of Radiology, 729 Arapeen Dr. University of Utah, 84108, Salt Lake City, Utah, USA;Department of Radiation Oncology, Stanford University, 94305, Stanford, CA, USA;

关键词: Myocardial Perfusion;    Cardiovascular Magnetic Resonance;    Myocardial Blood Flow;    Arterial Input Function;    Gadolinium Concentration;   

DOI  :  10.1186/1532-429X-12-45

 received in 2010-02-11, accepted in 2010-07-23,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundQuantitative estimates of myocardial perfusion generally require accurate measurement of the arterial input function (AIF). The saturation of signal intensity in the blood that occurs with most doses of contrast agent makes obtaining an accurate AIF challenging. This work seeks to evaluate the performance of a method that uses a radial k-space perfusion sequence and multiple saturation recovery times (SRT) to quantify myocardial perfusion with cardiovascular magnetic resonance (CMR).MethodsPerfusion CMR was performed at 3 Tesla with a saturation recovery radial turboFLASH sequence with 72 rays. Fourteen subjects were given a low dose (0.004 mmol/kg) of dilute (1/5 concentration) contrast agent (Gd-BOPTA) and then a higher non-dilute dose of the same volume (0.02 mmol/kg). AIFs were calculated from the blood signal in three sub-images with differing effective saturation recovery times. The full and sub-images were reconstructed iteratively with a total variation constraint. The images from the full 72 ray data were processed to obtain six tissue enhancement curves in two slices of the left ventricle in each subject. A 2-compartment model was used to determine absolute flowsResultsThe proposed multi-SRT method resulted in AIFs that were similar to those obtained with the dual-bolus method. Myocardial blood flow (MBF) estimates from the dual-bolus and the multi-SRT methods were related by MBFmulti-SRT = 0.85MBFdual-bolus + 0.18 (r = 0.91).ConclusionsThe multi-SRT method, which uses a radial k-space perfusion sequence, can be used to obtain an accurate AIF and thus quantify myocardial perfusion for doses of contrast agent that result in a relatively saturated AIF.

【 授权许可】

Unknown   
© Kim et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.