A blinded randomised controlled trial to determine the effect of enteric coating on enzyme treatment for canine exocrine pancreatic insufficiency

BMC Veterinary Research

Research Article

Peter Graham¹  Peter J Cripps²  Aran Mas²  Daniel J Batchelor²  Peter-John M Noble²  Alexander J German² 

[1] Nationwide Laboratories Lancefield House, 23 Mains Lane, Poulton-le-Fylde, United Kingdom;School of Veterinary Science, University of Liverpool, Neston, United Kingdom;

关键词: Dog;    Pancreas;    Malabsorption;    Diarrhoea;    Lipase;    Trypsin;   

DOI  :  10.1186/1746-6148-8-127

 received in 2012-04-02, accepted in 2012-07-28,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundEnzyme treatment is the mainstay for management of exocrine pancreatic insufficiency (EPI) in dogs. ‘Enteric-coated’ preparations have been developed to protect the enzyme from degradation in the stomach, but their efficacy has not been critically evaluated. The hypothesis of the current study was that enteric coating would have no effect on the efficacy of pancreatic enzyme treatment for dogs with EPI.Thirty-eight client-owned dogs with naturally occurring EPI were included in this multicentre, blinded, randomised controlled trial. Dogs received either an enteric-coated enzyme preparation (test treatment) or an identical preparation without the enteric coating (control treatment) over a period of 56 days.ResultsThere were no significant differences in either signalment or cobalamin status (where cobalamin deficient or not) between the dogs on the test and control treatments. Body weight and body condition score increased in both groups during the trial (P<0.001) but the magnitude of increase was greater for the test treatment compared with the control treatment (P<0.001). By day 56, mean body weight increase was 17% (95% confidence interval 11-23%) in the test treatment group and 9% (95% confidence interval 4-15%) in the control treatment group. The dose of enzyme required increased over time (P<0.001) but there was no significant difference between treatments at any time point (P=0.225). Clinical disease severity score decreased over time for both groups (P=0.011) and no difference was noted between groups (P=0.869). No significant adverse effects were reported, for either treatment, for the duration of the trial.ConclusionsEnteric coating a pancreatic enzyme treatment improves response in canine EPI.

【 授权许可】

Unknown   
© Mas et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.