Status epilepticus associated with platinum chemotherapy in a patient with cervical cancer: a case report

BMC Cancer

Case Report

Laura L. Holman¹  Shannon N. Westin¹  Yulan Ren² 

[1] Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Unit 1362, 1155 Herman Pressler, CPB6.3279, 77030-3721, Houston, TX, USA;Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, 159 Tianzhou Road, Xuhui Area, 200030, Shanghai, China;

关键词: Platinum chemotherapy;    Seizure;    Neurotoxicity;    Cervical cancer;   

DOI  :  10.1186/s12885-015-1755-2

 received in 2014-06-01, accepted in 2015-10-09,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundWhile peripheral neuropathy is a common side effect of platinum-based chemotherapy, central nervous system (CNS) toxicity, such as encephalopathy or seizures, appears to be rare. This manuscript describes the only reported case of nonconvulsive status epilepticus associated with cisplatin in a cervical cancer patient who does not have other underlying medical conditions.Case presentationThe patient is a 54-year-old Chinese female with recurrent stage IIIB moderately differentiated squamous cell carcinoma of the cervix who was being treated with cisplatin and topotecan. During the sixth cycle of this regimen, the patient presented with mental status changes. While imaging and laboratory values were within normal limits, the patient’s EEG revealed nonconvulsive status epilepticus. After appropriate intervention, she made a complete recovery with no further seizures. The patient currently remains on antiepileptic therapy, but is no longer receiving cisplatin.ConclusionPatients who present with new onset seizures should primarily be evaluated for underlying medical conditions. Among patients who are suspected to have CNS side effects associated with platinum use, we recommend avoidance of platinum agents in future chemotherapeutic regimens. Although rare, providers should be aware of the potential for CNS toxicity associated with this drug class.

【 授权许可】

CC BY   
© Holman et al. 2015