Young aboriginals are less likely to receive a renal transplant: a Canadian national study

BMC Nephrology

Research Article

Brenda Hemmelgarn¹  Leroy Storsley²  Julie Mojica²  Karen Yeates³  Paul Komenda⁴  Claudio Rigatto⁴  Navdeep Tangri⁴  Manish M Sood⁵  Steven Promislow⁵ 

[1] Department of Medicine, Section of Nephrology, Foothills Hospital, University of Calgary, 1403 29 Street, T2N2T9, Calgary, AL, Canada;Department of Medicine, Section of Nephrology, Health Sciences Centre, University of Manitoba, 820 Sherbrook street, R3A 1R9, Winnipeg, MB, Canada;Department of Medicine, Section of Nephrology, Kingston General Hospital, Queen’s University, 94 Stuart Street, K7L2V6, Kingston, ON, Canada;Department of Medicine, Section of Nephrology, Seven Oaks Hospital, University of Manitoba, 2300 McPhillips Street, R2V 3M3, Winnipeg, Canada;Department of Medicine, Section of Nephrology, St Boniface Hospital, University of Manitoba, 409 Tache Avenue, R2H 2A6, Winnipeg, Canada;

关键词: Renal Transplantation;    Living Donor;    Deceased Donor;    Dialysis Modality;    Dialysis Initiation;   

DOI  :  10.1186/1471-2369-14-11

 received in 2012-06-22, accepted in 2013-01-11,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundPrevious studies have demonstrated Aboriginals are less likely to receive a renal transplant in comparison to Caucasians however whether this applies to the entire population or specific subsets remains unclear. We examined the effect of age on renal transplantation in Aboriginals.MethodsData on 30,688 dialysis (Aboriginal 2,361, Caucasian 28, 327) patients obtained between Jan. 2000 and Dec. 2009 were included in the final analysis. Racial status was self-reported. Cox proportional hazards, the Fine and Grey sub-distribution method and Poisson regression were used to determine the association between race, age and transplantation.ResultsIn comparison to Caucasians, Aboriginals were less likely to receive a renal transplant (Adjusted HR 0.66 95% CI 0.57-0.77, P < 0.0001) however after stratification by age and treating death as a competing outcome, the effect was more predominant in younger Aboriginals (Age 18–40: 20.6% aboriginals vs. 48.3% Caucasians transplanted; aHR 0.50(0.39-0.61), p < 0.0001, Age 41–50: 10.2% aboriginals vs. 33.9% Caucasians transplanted; aHR 0.46(0.32-0.64), p = 0.005, Age 51–60: 8.2% aboriginals vs. 19.5% Caucasians transplanted; aHR0.65(0.49-0.88), p = 0.01, Age >60: 2.7% aboriginals vs. 2.6% Caucasians transplanted; aHR 1.21(0.76-1.91), P = 0.4, Age X race interaction p < 0.0001). Both living and deceased donor transplants were lower in Aboriginals under the age of 60 compared to Caucasians.ConclusionYounger Aboriginals are less likely to receive a renal transplant compared to their Caucasian counterparts, even after adjustment for comorbidity. Determination of the reasons behind these discrepancies and interventions specifically targeting the Aboriginal population are warranted.

【 授权许可】

Unknown   
© Promislow et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.