Formation and stability of oil-in-water nanoemulsions containing rice bran oil: in vitro and in vivo assessments

Journal of Nanobiotechnology

Research

Daniela S Bernardi¹  Pedro A Rocha-Filho¹  Tatiana A Pereira¹  Naira R Maciel¹  Gisely S Viera¹  Gustavo C Oliveira¹  Josiane Bortoloto² 

[1] Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil;Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil;Universidade de Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil;

关键词: Psoriasis;    Atopic Dermatitis;    Droplet Size;    Chorioallantoic Membrane;    Skin Hydration;   

DOI  :  10.1186/1477-3155-9-44

 received in 2011-04-11, accepted in 2011-09-28,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundNanoemulsions have practical application in a multitude of commercial areas, such as the chemical, pharmaceutical and cosmetic industries. Cosmetic industries use rice bran oil in sunscreen formulations, anti ageing products and in treatments for skin diseases. The aim of this study was to create rice bran oil nanoemulsions using low energy emulsification methods and to evaluate their physical stability, irritation potential and moisturising activity on volunteers with normal and diseased skin types.ResultsThe nanoemulsion developed by this phase diagram method was composed of 10% rice bran oil, 10% surfactants sorbitan oleate/PEG-30 castor oil, 0.05% antioxidant and 0.50% preservatives formulated in distilled water. The nanoemulsion was stable over the time course of this study. In vitro assays showed that this formulation has a low irritation potential, and when applied to human skin during in vivo studies, the nanoemulsion improved the skin's moisture and maintained normal skin pH values.ConclusionThe results of irritation potential studies and in vivo assessments indicate that this nanoemulsion has potential to be a useful tool to treat skin diseases, such as atopic dermatitis and psoriasis.

【 授权许可】

CC BY   
© Bernardi et al; licensee BioMed Central Ltd. 2011