Association of KCTD10, MVK, and MMAB polymorphisms with dyslipidemia and coronary heart disease in Han Chinese population

Lipids in Health and Disease

Research

Yun Qian¹  Jiaping Chen²  Jie Sun²  Yue Jiang²  Guangfu Jin²  Chong Shen²  Zhibin Hu²  Juncheng Dai²  Hongbing Shen²  Sijun Liu³  Jianming Wang³ 

[1] Department of Chronic Non-communicable Disease Control, Wuxi Center for Disease Control and Prevention, 214023, Wuxi, China;Department of Epidemiology, School of Public Health, Nanjing Medical University, 101 Longmian AV., 211166, Nanjing, Jiangsu, China;Department of Epidemiology, School of Public Health, Nanjing Medical University, 101 Longmian AV., 211166, Nanjing, Jiangsu, China;Department of Social Medicine and Health Education, School of Public Health, Nanjing Medical University, 101 Longmian AV., 211166, Nanjing, Jiangsu, China;

关键词: MVK;    MMAB;    KCTD10;    HDL-C;    Coronary heart disease;   

DOI  :  10.1186/s12944-016-0348-7

 received in 2016-05-13, accepted in 2016-09-30,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundSeveral genome-wide association studies have discovered novel loci at chromosome 12q24, which includes mevalonate kinase (MVK), methylmalonic aciduria (cobalamin deficiency) cbIB type (MMAB), and potassium channel tetramerization domain-containing 10 (KCTD10), all of which influence HDL-cholesterol concentrations. However, there are few reports on the associations between these polymorphisms and HDL-C concentrations in Chinese population. This study aimed to evaluate the associations between functional polymorphisms in three genes (MVK, MMAB and KCTD10) and HDL-C concentrations, as well as coronary heart disease (CHD) susceptibility in Chinese individuals.MethodsWe systematically selected and genotyped 18 potentially functional polymorphisms in MVK, MMAB and KCTD10 by using the TaqMan OpenArray Genotyping System in a Chinese population including 399 dyslipidemia cases, 697 CHD cases and 465 controls. Multivariate logistic regression analyses were performed to estimate the relationship between the genotypes and dyslipidemia, CHD risk with adjustment of relevant confounders.ResultsAmong six polymorphisms showing significant associations with dyslipidemia, the minor alleles of rs11066782 in KCTD10, rs11613718 in KCTD10 and rs11067233 in MMAB were significantly associated with a decreased risk of CHD (additive model: OR = 0.71, 95 % CI = 0.53–0.97, P = 0.029 for rs11066782; OR = 0.73, 95 % CI = 0.54–0.99, P = 0.044 for rs11613718 and OR = 0.57, 95 % CI = 0.40–0.80, P = 0.001 for rs11067233). Further combined analysis showed that individuals carrying “3-4” favorable alleles presented a 62 % (OR = 0.38, 95 % CI = 0.21–0.66) decreased risk of CHD compared with those carrying “0–2” favorable alleles.ConclusionsThese findings suggest that rs11066782 in KCTD10, rs11613718 in KCTD10 and rs11067233 in MMAB may contribute to the susceptibility of CHD by altering plasma HDL-C levels in Han Chinese.

【 授权许可】

CC BY   
© The Author(s). 2016