Degenerative changes of the canine cervical spine after discectomy procedures, an in vivo study

BMC Veterinary Research

Research Article

Rodolfo J. Ricart Arbona¹  Lawrence J. Bonassar²  Roger Härtl³  Yu Moriguchi³  Peter Grunert⁴  Brian P. Grossbard⁵ 

[1] Center of Comparative Medicine and Pathology, Memorial Sloan Kettering Cancer Center & Weill Cornell Medicine, New York City, NY, USA;Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA;Department of Neurological Surgery, Weill Cornell Medicine, New York-Presbyterian Hospital, Weill Cornell Brain and Spine Institute

[2] , Box 99, 525 East 68th Street, 10065, New York, NY, USA;Department of Neurological Surgery, Weill Cornell Medicine, New York-Presbyterian Hospital, Weill Cornell Brain and Spine Institute

[3] , Box 99, 525 East 68th Street, 10065, New York, NY, USA;Department of Neurological Surgery, Swedish Neuroscience Institute, Seattle, WA, USA;Department of Orthopedics and Neurosurgery VCA-Animal Specialty, Yonkers, NY, USA;

关键词: Canine spine;    Discectomy;    Degeneration;    Disc herniation;    Disc fenestration;    Nucleus pulposus;    Annulus fibrosus;    Quantitative MRI;   

DOI  :  10.1186/s12917-017-1105-5

 received in 2017-03-06, accepted in 2017-06-09,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundDiscectomies are a common surgical treatment for disc herniations in the canine spine. However, the effect of these procedures on intervertebral disc tissue is not fully understood. The objective of this study was to assess degenerative changes of cervical spinal segments undergoing discectomy procedures, in vivo.ResultsDiscectomies led to a 60% drop in disc height and 24% drop in foraminal height. Segments did not fuse but showed osteophyte formation as well as endplate sclerosis. MR imaging revealed terminal degenerative changes with collapse of the disc space and loss of T2 signal intensity. The endplates showed degenerative type II Modic changes. Quantitative MR imaging revealed that over 95% of Nucleus Pulposus tissue was extracted and that the nuclear as well as overall disc hydration significantly decreased. Histology confirmed terminal degenerative changes with loss of NP tissue, loss of Annulus Fibrosus organization and loss of cartilage endplate tissue. The bony endplate displayed sclerotic changes.ConclusionDiscectomies lead to terminal degenerative changes. Therefore, these procedures should be indicated with caution specifically when performed for prophylactic purposes.

【 授权许可】

CC BY   
© The Author(s). 2017