Repeated measures of inflammation, blood pressure, and heart rate variability associated with traffic exposures in healthy adults

Environmental Health

Research

Terry Gordon¹  Lung-Chi Chen¹  George Thurston¹  Jaime E. Mirowsky¹  Morton Lippmann¹  Robert Laumbach²  Richard E. Peltier³  David Diaz-Sanchez⁴  Jacqueline D. Carter⁴  Lucas Neas⁵ 

[1] Department of Environmental Medicine, New York University, Tuxedo, NY, USA;Department of Environmental and Occupational Medicine, University of Medicine and Dentistry of New Jersey, Piscataway, NJ, USA;Division of Environmental Health Science, University of Massachusetts, Amherst, MA, USA;U.S. EPA; Environmental Public Health Division, Chapel Hill, NC, USA;U.S. EPA; Epidemiology Branch, Chapel Hill, NC, USA;

关键词: Air pollution;    Health effects;    Traffic;    Biomarkers;   

DOI  :  10.1186/s12940-015-0049-0

 received in 2015-03-05, accepted in 2015-07-09,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundPrevious human exposure studies of traffic-related air pollutants have demonstrated adverse health effects in human populations by comparing areas of high and low traffic, but few studies have utilized microenvironmental monitoring of pollutants at multiple traffic locations while looking at a vast array of health endpoints in the same population. We evaluated inflammatory markers, heart rate variability (HRV), blood pressure, exhaled nitric oxide, and lung function in healthy participants after exposures to varying mixtures of traffic pollutants.MethodsA repeated-measures, crossover study design was used in which 23 healthy, non-smoking adults had clinical cardiopulmonary and systemic inflammatory measurements taken prior to, immediately after, and 24 hours after intermittent walking for two hours in the summer months along three diverse roadways having unique emission characteristics. Measurements of PM2.5, PM10, black carbon (BC), elemental carbon (EC), and organic carbon (OC) were collected. Mixed effect models were used to assess changes in health effects associated with these specific pollutant classes.ResultsMinimal associations were observed with lung function measurements and the pollutants measured. Small decreases in BP measurements and rMSSD, and increases in IL-1β and the low frequency to high frequency ratio measured in HRV, were observed with increasing concentrations of PM2.5 EC.ConclusionsSmall, acute changes in cardiovascular and inflammation-related effects of microenvironmental exposures to traffic-related air pollution were observed in a group of healthy young adults. The associations were most profound with the diesel-source EC.

【 授权许可】

CC BY   
© Mirowsky et al. 2015

【 图 表 】

Fig. 4