Role of long non-coding RNAs in glucose metabolism in cancer

Molecular Cancer

Review

Liting Yang¹  Jinpeng Wang¹  Can Guo¹  Fang Wei¹  Yi He¹  Yanyan Tang¹  Zhaojian Gong¹  Fang Xiong²  Shanshan Zhang²  Yumin Wang³  Wei Xiong⁴  Ming Zhou⁴  Guiyuan Li⁴  Chunmei Fan⁴  Zhaoyang Zeng⁴  Xiaoling Li⁴ 

[1] The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China;The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China;The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China;The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China;The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China;The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China;Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China;

关键词: LncRNAs;    Glucose metabolism;    Warburg effect;    Signaling pathway;    Targeted therapy;   

DOI  :  10.1186/s12943-017-0699-3

 received in 2017-03-14, accepted in 2017-07-11,  发布年份 2017

来源: Springer

【 摘 要 】

Long-noncoding RNAs (lncRNAs) are a group of transcripts that are longer than 200 nucleotides and do not code for proteins. However, this class of RNAs plays pivotal regulatory roles. The mechanism of their action is highly complex. Mounting evidence shows that lncRNAs can regulate cancer onset and progression in a variety of ways. They can not only regulate cancer cell proliferation, differentiation, invasion and metastasis, but can also regulate glucose metabolism in cancer cells through different ways, such as by directly regulating the glycolytic enzymes and glucose transporters (GLUTs), or indirectly modulating the signaling pathways. In this review, we summarized the role of lncRNAs in regulating glucose metabolism in cancer, which will help understand better the pathogenesis of malignant tumors. The understanding of the role of lncRNAs in glucose metabolism may help provide new therapeutic targets and novel diagnostic and prognosis markers for human cancer.

【 授权许可】

CC BY   
© The Author(s). 2017