Anti-oxidant effect of gold nanoparticles restrains hyperglycemic conditions in diabetic mice

Journal of Nanobiotechnology

Research

Sangiliyandi Gurunathan¹  SureshBabu Ram Kumar Pandian¹  Muthuirulappan Sriram¹  Selvaraj BarathManiKanth¹  Kalimuthu Kalishwaralal¹  Hyung-seop Youn²  SooHyun Eom² 

[1] Department of Biotechnology, Division of Molecular and Cellular Biology, Kalasalingam University, Anand Nagar, 626190, Krishnankoil, Tamilnadu, India;Systems Biology Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, 500-712, Gwangju, South Korea;

关键词: Gold Nanoparticles;    Inductively Couple Plasma Mass Spectrometry;    Reactive Oxygen Species Generation;    Diabetic Mouse;    Diabetic Control;   

DOI  :  10.1186/1477-3155-8-16

 received in 2010-03-15, accepted in 2010-07-14,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundOxidative stress is imperative for its morbidity towards diabetic complications, where abnormal metabolic milieu as a result of hyperglycemia, leads to the onset of several complications. A biological antioxidant capable of inhibiting oxidative stress mediated diabetic progressions; during hyperglycemia is still the need of the era. The current study was performed to study the effect of biologically synthesized gold nanoparticles (AuNPs) to control the hyperglycemic conditions in streptozotocin induced diabetic mice.ResultsThe profound control of AuNPs over the anti oxidant enzymes such as GSH, SOD, Catalase and GPx in diabetic mice to normal, by inhibition of lipid peroxidation and ROS generation during hyperglycemia evidence their anti-oxidant effect during hyperglycemia. The AuNPs exhibited an insistent control over the blood glucose level, lipids and serum biochemical profiles in diabetic mice near to the control mice provokes their effective role in controlling and increasing the organ functions for better utilization of blood glucose. Histopathological and hematological studies revealed the non-toxic and protective effect of the gold nanoparticles over the vital organs when administered at dosage of 2.5 mg/kilogram.body.weight/day. ICP-MS analysis revealed the biodistribution of gold nanoparticles in the vital organs showing accumulation of AuNPs in the spleen comparatively greater than other organs.ConclusionThe results obtained disclose the effectual role of AuNPs as an anti-oxidative agent, by inhibiting the formation of ROS, scavenging free radicals; thus increasing the anti-oxidant defense enzymes and creating a sustained control over hyperglycemic conditions which consequently evoke the potential of AuNPs as an economic therapeutic remedy in diabetic treatments and its complications.

【 授权许可】

Unknown   
© BarathManiKanth et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.