Sex-based influential factors for dental caries in patients with schizophrenia

BMC Psychiatry

Research

Xiangyang Zhang¹  Zezhi Li²  Jingjing Xu³  Xiaoqin Chen³  Yan Yang⁴  Wei Chen⁴  Di Kong⁴  Mi Yang⁵  Liju Liu⁶ 

[1] CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, 100101, Beijing, China;Department of Nutritional and Metabolic Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University, 36 Mingxin Road, Liwan District, 510370, Guangzhou, China;Department of Psychiatry, Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, 36 Mingxin Road, Liwan District, 510370, Guangzhou, China;Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province, Ministry of Education of China, Guangzhou Medical University, 36 Mingxin Road, Liwan District, 510370, Guangzhou, China;Department of Psychiatry, Qingdao mental health center, No. 299, Nanjing Road, 266034, Qingdao, China;Department of Psychiatry, The Fourth People’s Hospital of Chengdu, No.8 Huli-West 1st-Alley, Jinniu District, 610036, Chengdu, China;Department of Psychiatry, The Fourth People’s Hospital of Chengdu, No.8 Huli-West 1st-Alley, Jinniu District, 610036, Chengdu, China;MOE Key Lab for Neuroinformation, The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Qingshuihe Campus: No.2006, Xiyuan Ave, West Hi-Tech Zone, 611731, Chengdu, China;School of Life Science and Technology, University of Electronic Science and Technology of China, Qingshuihe Campus: No.2006, Xiyuan Ave, West Hi-Tech Zone, 611731, Chengdu, China;School of Life Science and Technology, University of Electronic Science and Technology of China, Qingshuihe Campus: No.2006, Xiyuan Ave, West Hi-Tech Zone, 611731, Chengdu, China;

关键词: Sex difference;    Schizophrenia;    Caries;    Cognition;    Diabetes;    Smoking;   

DOI  :  10.1186/s12888-023-05256-z

 received in 2023-06-15, accepted in 2023-10-04,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundSchizophrenia is a common mental disorder that seriously affects patients’ daily lives and brings heavy psychological and economic burdens to their families and society. The oral problems of patients with schizophrenia are gradually gaining attention, among which dental caries are among the most common oral diseases. Sex differences may be related not only to the various clinical symptoms of schizophrenia but also to different oral hygiene statuses; therefore, the main purpose of this paper is to investigate sex differences related to influencing factors for dental caries in patients with schizophrenia.MethodInpatients with schizophrenia over 18 years old were included in this study, and multidimensional indicators such as demographics, symptom and cognitive impairment assessments, medications, and the caries index of decayed, missing, and filled teeth (DMFT) were collected. An analysis of sex-based influential factors for dental caries in schizophrenia patients was performed.ResultsFour-hundred and ninety-six patients with schizophrenia were included, with a mean age of 46.73 ± 12.23 years, of which 142 were females and 354 were males. The mean DMFT was significantly higher in males (8.81 ± 8.50) than in females (5.63 ± 6.61, p < 0.001), and the odd ratio of caries in males to females was significantly higher as well (OR = 2.305, p < 0.001). The influential factors of caries in male patients were independently associated with age and smoking status, in which current smokers were at the highest risk for developing caries, and different smoking statuses had various influencing factors for caries. The influencing factors for caries in female patients were independently associated with age, antipsychotic dose, PANSS-positive symptoms, and MMSE levels.ConclusionOur findings suggest sex differences exist among influential factors for caries in patients with schizophrenia. These risk factors may even be associated with and affect the treatment and prognosis of psychiatric symptoms in patients. Therefore, oral hygiene management of patients with schizophrenia should be enhanced. These differential factors provide new visions and ideas for formulating individual interventions, treatments, and care priorities.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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