Reported adverse events related to use of hepatitis C virus direct-acting antivirals with opioids: 2017–2021

Harm Reduction Journal

Brief Report

Anthony Martinez¹  Brad Saget²  Michelle Collins³  John Marcinak⁴  Douglas E. Dylla⁵  Brian Conway⁶  Tipu Khan⁷ 

[1] Department of Medicine, Jacobs School of Medicine, University at Buffalo, State University of New York, 955 Main Street, 14203, Buffalo, NY, USA;Global Medical Affairs – Virology/Hepatology, AbbVie Inc., North Chicago, IL, USA;Global Medical Affairs, AbbVie Inc., North Chicago, IL, USA;Infectious Diseases Therapeutic Area, AbbVie Inc., North Chicago, IL, USA;US Medical Affairs – Virology, AbbVie Inc., North Chicago, IL, USA;Vancouver Infectious Diseases Centre, Vancouver, Canada;Simon Fraser University, Burnaby, Canada;Ventura County Medical Center, Ventura, CA, USA;

关键词: Addiction;    Clinical populations;    Hepatitis;    Safety;    Substance abuse;   

DOI  :  10.1186/s12954-023-00874-y

 received in 2023-07-26, accepted in 2023-09-24,  发布年份 2023

来源: Springer

【 摘 要 】

IntroductionDue to concerns over potential interactions between some hepatitis C direct-acting antivirals (DAAs) and opioids, we describe adverse event (AE) reports of concomitant use of opioids and DAAs.MethodsAEs reported (July 28, 2017–December 31, 2021) with the administration of the DAAs glecaprevir/pibrentasvir, sofosbuvir/velpatasvir, ledipasvir/sofosbuvir, sofosbuvir/velpatasvir/voxilaprevir, and elbasvir/grazoprevir as suspect products were downloaded from the US Food and Drug Administration AE Reporting System Public Dashboard. The number of AE reports containing opioids (fentanyl, hydrocodone, oxycodone) as co-suspect products/concomitant products were counted and summarized by severity, reporting country and whether an outcome of death was reported. Overdose AEs were counted irrespective of opioid use, and changes over time were assessed.ResultsIn total, 40 AEs were reported for DAAs and concomitant fentanyl use, 25 (62.5%) were in the USA, 35 (87.5%) were considered serious, and 14 (35.0%) resulted in death; and 626 were reported with concomitant oxycodone/hydrocodone use, 596 (95.2%) were in the USA, 296 (47.3%) were considered serious, and 28 (4.5%) resulted in death. There were 196 overdose AEs (32 [16%] deaths) declining from 2018 (N = 56) to 2021 (N = 29).ConclusionsTreating people with hepatitis C virus (HCV) infection who use drugs is key to achieving HCV elimination. Low numbers of DAA AE reports with opioids may provide reassurance to prioritize HCV treatment in this population. These data contribute to evidence supporting the continued scale-up of DAA treatment among people who use drugs to achieve HCV elimination goals.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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