APOE polymorphism is associated with lipid profile, but not with arterial stiffness in the general population

Lipids in Health and Disease

Research

José G Mill¹  Roberto S Cunha¹  Silvia RS Freitas²  José E Krieger²  Rafael O Alvim²  Paulo CJL Santos²  Noely E Ferreira²  Alexandre C Pereira² 

[1] Department of Physiology, Espírito Santo Federal University, Brazil;Heart Institute (InCor), University of São Paulo Medical School, Brazil;

关键词: Uric Acid;    Arterial Stiffness;    Pulse Wave Velocity;    Hyperuricemia;    Uric Acid Level;   

DOI  :  10.1186/1476-511X-9-128

 received in 2010-07-06, accepted in 2010-11-08,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundCardiovascular diseases (CVD) are the main cause of death and disability in developed countries. In most cases, the progress of CVD is influenced by environmental factors and multifactorial inheritance. The purpose of this study was to investigate the association between APOE genotypes, cardiovascular risk factors, and a non-invasive measure of arterial stiffness in the Brazilian population.MethodsA total of 1493 urban Brazilian individuals were randomly selected from the general population of the Vitoria City Metropolitan area. Genetic analysis of the APOE polymorphism was conducted by PCR-RFLP and pulse wave velocity analyzed with a noninvasive automatic device.ResultsAge, gender, body mass index, triglycerides, creatinine, uric acid, blood glucose, blood pressure phenotypes were no different between ε2, ε3 and ε4 alleles. The ε4 allele was associated with higher total-cholesterol (p < 0.001), LDL-C (p < 0.001), total-cholesterol/HDL-C ratio (p < 0.001), LDL/HDL-C ratio (p < 0.001), lower HDL-C values (p < 0.001) and higher risk to obesity (OR = 1.358, 95% CI = 1.019-1.811) and hyperuricemia (OR = 1.748, 95% CI = 1.170-2.611). Nevertheless, pulse wave velocity (p = 0.66) measures were no different between genotypes. The significant association between APOE genotypes and lipid levels persisted after a 5-year follow-up interval, but no interaction between time and genotype was observed for lipids longitudinal behavior.ConclusionThe ε4 allele of the APOE gene is associated with a worse lipid profile in the Brazilian urban population. In our relatively young sample, the observed effect of APOE genotype on lipid levels was not translated into significant effects in arterial wall stiffness.

【 授权许可】

Unknown   
© Alvim et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.