Electrocardiographic changes with the onset of diabetes and the impact of aerobic exercise training in the Zucker Diabetic Fatty (ZDF) rat

Cardiovascular Diabetology

Original Investigation

Muhammed Al-Jarrah¹  Rajprasad Loganathan²  Lesya Novikova²  Lisa Stehno-Bittel²  Irina V Smirnova²  Lisa VanHoose²  James L Vacek³  Youssef Sawers³ 

[1] Department of Allied Medical Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, 22110, Irbid, Jordan;Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, MS 2002, 3901 Rainbow Blvd, 66160, Kansas City, KS, USA;Mid America Cardiology, University of Kansas Hospital, MS 4023, 3901 Rainbow Blvd, 66160, Kansas City, KS, USA;

关键词: Heart Rate Variability;    Exercise Training;    Wave Amplitude;    Diabetic Animal;    Aerobic Exercise Training;   

DOI  :  10.1186/1475-2840-9-56

 received in 2010-08-05, accepted in 2010-09-22,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundEarly markers of diabetic autonomic neuropathy (DAN) in an electrocardiogram (ECG) include elevated R wave amplitudes, widening of QTc intervals and decreased heart rate variability (HRV). The severity of DAN has a direct relationship with mortality risk. Aerobic exercise training is a common recommendation for the delay and possible reversal of cardiac dysfunction. Limited research exists on ECG measures for the evaluation of aerobic exercise training in Zucker Diabetic Fatty (ZDF) rat, a model of type 2 diabetes. The objective of this study was to assess whether aerobic exercise training may attenuate diabetes induced ECG changes.MethodsMale ZDF (obese fa/fa) and control Zucker (lean fa/+) rats were assigned to 4 groups: sedentary control (SC), sedentary diabetic (SD), exercised control (EC) and exercised diabetic (ED). The exercised groups began 7 weeks of treadmill training after the development of diabetes in the ED group. Baseline (prior to the training) and termination measurements included body weight, heart weight, blood glucose and glycated hemoglobin levels and ECG parameters. One way repeated measures ANOVA (group) analyzed within and between subject differences and interactions. Pearson coefficients and descriptive statistics described variable relationships and animal characteristics.ResultsDiabetes caused crucial changes in R wave amplitudes (p < 0.001), heart rate variability (p < 0.01), QT intervals (p < 0.001) and QTc intervals (p < 0.001). R wave amplitude augmentation in SD rats from baseline to termination was ameliorated by exercise, resulting in R wave amplitude changes in ED animals similar to control rats. Aerobic exercise training neither attenuated QT or QTc interval prolongation nor restored decreases in HRV in diabetic rats.ConclusionThis study revealed alterations in R wave amplitudes, HRV, QT and QTc intervals in ZDF rats. Of these changes, aerobic exercise training was able to correct R wave amplitude changes. In addition, exercise has beneficial effect in this diabetic rat model in regards to ECG correlates of left ventricular mass.

【 授权许可】

Unknown   
© VanHoose et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.