Value of diffusion-weighted imaging combined with conventional magnetic resonance imaging in the diagnosis of thecomas/fibrothecomas and their differential diagnosis with malignant pelvic solid tumors

World Journal of Surgical Oncology

Research

Ping Zhang¹  Xiangru Wu²  Caiting Chu³  Jian Chen³  Ming Ding³  Bing Yin³  Wenhua Li³  Yanfen Cui³ 

[1] Department of Obstetrics and Gynecology, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 200092, Shanghai, China;Department of Pathology, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 200092, Shanghai, China;Department of Radiology, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 200092, Shanghai, China;

关键词: Thecoma;    Malignant pelvic solid tumors;    Conventional magnetic resonance imaging;    Diffusion-weighted imaging;    Apparent diffusion coefficient value;   

DOI  :  10.1186/s12957-015-0760-x

 received in 2015-08-28, accepted in 2015-12-30,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundOur study aims to determine the value of diffusion-weighted imaging (DWI) combined with conventional magnetic resonance imaging (MRI) in the diagnosis of thecomas/fibrothecomas and their differential diagnosis with malignant pelvic solid tumors.MethodsIn total, 36 thecomas/fibrothecomas and 40 malignant pelvic solid tumors were included in our study. All patients underwent 1.5 T conventional MRI and DWI examinations except one patient with a fibrothecoma in whom DWI examination was not performed. The clinical features and characteristics of conventional MRI and DWI of these two groups were analyzed. Apparent diffusion coefficient (ADC) values were measured and compared between groups. Univariate analysis, multivariate logistic regression analysis, and the receiver operating characteristic curve were used for statistical analysis.ResultsAll the thecomas/fibrothecomas showed isointensity on T1 weighted imaging (T1WI) and 77.8 % (28/36) lesions showed hypo- to isointensity on T2 weighted imaging (T2WI). After administration of contrast medium, 94.4 % (34/36) tumors appeared as minor to mild enhancement. On DWI, they showed a diversity of low to very high signal intensity. All malignant pelvic masses manifested as hyperintensity on T2WI and 87.5 % (35/40) tumors showed very high signal (grade 3) on DWI. Higher area under the curve (AUC) and specificity could be achieved by using the lowest ADC value than the mean ADC value. Multivariate logistic regression analysis showed that shape, signal intensity on T2WI, capsule, and the lowest ADC value were the important indicators in discriminating thecomas/fibrothecomas from malignant pelvic solid tumors.ConclusionsThe combination of DWI and conventional MRI is of great value in the diagnosis of thecomas/fibrothecomas and their differential diagnosis with malignant pelvic solid tumors.

【 授权许可】

CC BY   
© Yin et al. 2016