Altered sphingoid base profiles in type 1 compared to type 2 diabetes

Lipids in Health and Disease

Short Report

Rodica Pop-Busui¹  Nancy Wei²  Alaa Othman³  Thorsten Hornemann³  Irina Alecu³  Jessica Pan⁴  Florian S Eichler⁵ 

[1] Department of Internal Medicine, Metabolism Endocrinology and Diabetes, University of Michigan Health System, 1500 E. Medical Center Drive, 48109, Ann Arbor, MI, USA;Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, 02114, Boston, MA, USA;Institute for Clinical Chemistry, University Hospital Zurich, Rämistrasse 100, 8091, Zürich, Switzerland;MGH Neuroscience Center, Department of Neurology, Harvard Medical School, 55 Fruit Street ACC 708, 02114, Boston, MA, USA;MGH Neuroscience Center, Department of Neurology, Harvard Medical School, 55 Fruit Street ACC 708, 02114, Boston, MA, USA;Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, ACC 708, 02114, Boston, MA, USA;

关键词: Atypical sphingolipids;    Biomarker;    Deoxysphingolipids;    Metabolic syndrome;    Type 2 diabetes mellitus;    Type 1 diabetes mellitus;   

DOI  :  10.1186/1476-511X-13-161

 received in 2014-05-20, accepted in 2014-09-27,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundSphingolipids are increasingly recognized to play a role in insulin resistance and diabetes. Recently we reported significant elevations of 1-deoxysphingolipids (1-deoxySL) - an atypical class of sphingolipids in patients with metabolic syndrome (MetS) and diabetes type 2 (T2DM). It is unknown whether 1-deoxySL in patients with diabetes type 1 (T1DM) are similarly elevated.FindingsWe analyzed the long chain base profile by LC-MS after hydrolyzing the N-acyl and O-linked headgroups in plasma from individuals with T1DM (N = 27), T2DM (N = 30) and healthy controls (N = 23). 1-deoxySLs were significantly higher in the groups with T2DM but not different between T1DM and controls. In contrast to patients with T2DM, 1-deoxSL levels are not elevated in T1DM.ConclusionsOur study indicates that the 1-deoxySL formation is not per-se caused by hyperglycemia but rather specifically associated with metabolic changes in T2DM, such as elevated triglyceride levels.

【 授权许可】

Unknown   
© Wei et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.