Gene expression in notochord and nuclei pulposi: a study of gene families across the chordate phylum

BMC Ecology and Evolution

Research

Abdullah M. Ali¹  Jean-Pierre Saint-Jeannet²  Anna Di Gregorio²  Julie E. Maguire²  Lenny J. Negrón-Piñeiro²  Chibuike Ihewulezi²  Yushi Wu²  Han Jo Kim³  Todd J. Albert³  Matthew Cunningham³  Rahul Raghavan⁴  Justin Hong⁴  Chitra L. Dahia⁵  Filomena Ristoratore⁶  Ugo Coppola⁷ 

[1] Department of Medicine, Columbia University Irving Medical Center, 10032, New York, NY, USA;Department of Molecular Pathobiology, New York University College of Dentistry, 10010, New York, NY, USA;Hospital for Special Surgery, 10021, New York, NY, USA;Weill Cornell Medical College, 10065, New York, NY, USA;Hospital for Special Surgery, Orthopedic Soft Tissue Research Program, 10021, New York, NY, USA;Hospital for Special Surgery, Orthopedic Soft Tissue Research Program, 10021, New York, NY, USA;Department of Cell and Developmental Biology, Weill Cornell Medicine, Graduate School of Medical Science, 10065, New York, NY, USA;Stazione Zoologica ‘A. Dohrn’, Villa Comunale 1, 80121, Naples, Italy;Stazione Zoologica ‘A. Dohrn’, Villa Comunale 1, 80121, Naples, Italy;Present Address: Molecular Cardiovascular Biology Division and Heart Institute, Cincinnati Children’s Research Foundation, 45229, Cincinnati, OH, USA;

关键词: Ciona;    Coronin;    Human;    Mouse;    Notochord;    Nucleus pulposus;    Phip;    Rgm;    Rgs;    Tmod;    Xenopus;    Zebrafish;   

DOI  :  10.1186/s12862-023-02167-1

 received in 2023-06-04, accepted in 2023-08-08,  发布年份 2023

来源: Springer

【 摘 要 】

The transition from notochord to vertebral column is a crucial milestone in chordate evolution and in prenatal development of all vertebrates. As ossification of the vertebral bodies proceeds, involutions of residual notochord cells into the intervertebral discs form the nuclei pulposi, shock-absorbing structures that confer flexibility to the spine. Numerous studies have outlined the developmental and evolutionary relationship between notochord and nuclei pulposi. However, the knowledge of the similarities and differences in the genetic repertoires of these two structures remains limited, also because comparative studies of notochord and nuclei pulposi across chordates are complicated by the gene/genome duplication events that led to extant vertebrates. Here we show the results of a pilot study aimed at bridging the information on these two structures. We have followed in different vertebrates the evolutionary trajectory of notochord genes identified in the invertebrate chordate Ciona, and we have evaluated the extent of conservation of their expression in notochord cells. Our results have uncovered evolutionarily conserved markers of both notochord development and aging/degeneration of the nuclei pulposi.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 7

12951_2017_255_Article_IEq54.gif

Fig. 5

12951_2017_255_Article_IEq53.gif

Fig. 2

12888_2023_5292_Article_IEq1.gif

Fig. 1

Fig. 1

Fig. 2

Fig. 1

Fig. 3

Fig. 5

Fig. 2

Fig. 1

Fig. 2

12951_2016_246_Article_IEq7.gif

12951_2015_155_Article_IEq78.gif

Fig. 3

12951_2016_246_Article_IEq3.gif

Fig. 3

Fig. 2

Fig. 2

Fig. 3

Fig. 2