Prognostic significance of heart rate turbulence parameters in patients with chronic heart failure

BMC Cardiovascular Disorders

Research Article

Hong-Yu Xie¹  De-Chun Yin¹  Zhao-Jun Wang¹  Wei Qiu¹  Lin Sun¹  Shuai Guo¹  Wei Feng¹  Xiu-Fen Qu² 

[1] Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, 150001, Harbin, P.R. China;Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, 150001, Harbin, P.R. China;Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Dazhi Street No.199, 150001, Nangang District, Harbin, P.R. China;

关键词: Heart rate turbulence;    Chronic heart failure;    Prognosis;   

DOI  :  10.1186/1471-2261-14-50

 received in 2013-12-19, accepted in 2014-04-03,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThis study is aimed to evaluate the clinical significance of heart rate turbulence (HRT) parameters in predicting the prognosis in patients with chronic heart failure (CHF).MethodsFrom June 2011 to December 2012, a total of 104 CHF patients and 30 healthy controls were enrolled in this study. We obtained a 24-hour Holter ECG recording to assess the HRT parameters, included turbulence onset (TO), turbulence slope (TS), standard deviation of N-N intervals (SDNN), and resting heart rate (RHR). The relationships between HRT parameters and the prognosis of CHF patients were determined.ResultsThe assessment follow-up period lasted until January 31, 2013. The overall mortality of CHF patients was 9.6% (10/104). Our results revealed that CHF patients had higher levels of TO than those of healthy subjects, but the TS levels of CHF patients were lower than that of the control group. CHF patients with NYHA grade IV had higher HRT1/2 rate than those with NYHA grade II/III. There were statistical differences in TS, LVEF, SDNN and RHR between the non-deteriorating group and the non-survivor group. Significant differences in TS among the three groups were also found. Furthermore, CHF patients in the non-survivor group had lower levels of TS than those in the deteriorating group. Correlation analyses indicated that TO negatively correlate with SDNN, while TS positively correlated with SDNN and left ventricular ejection fraction (LVEF). We also observed negative correlations between TS and left ventricular end-diastolic cavity dimension (LVEDD), RHR, homocysteine (Hcy) and C-reactive protein (CRP). Multivariate Cox regression analysis further confirmed that LVEF (≤30%), HRT2, SDNN and RHR were independent risk factors which can indicate poor prognosis in CHF patients.ConclusionsOur findings indicate that HRT may have good clinical predictive value in patients with CHF. Thus, quantifying HRT parameters could be a useful tool for predicting mortality in CHF patients.

【 授权许可】

Unknown   
© Yin et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.