Application prospective of nanoprobes with MRI and FI dual-modality imaging on breast cancer stem cells in tumor

Journal of Nanobiotechnology

Review

Yu Wang¹  Chunhui Xia¹  Hetao Chen²  Zengrong Sun²  Dongxing Shi²  Tong Wang²  Baiqi Wang² 

[1] Department of Chemistry, Qiqihaer Medical College, 161006, Qiqihaer, Heilongjiang Province, China;Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, No. 22, Qixiangtai Road, Heping District, 300070, Tianjin, China;

关键词: Breast cancer;    Cancer stem cells;    Magnetic resonance;    Fluorescence;    Imaging;   

DOI  :  10.1186/s12951-016-0195-8

 received in 2015-12-16, accepted in 2016-05-20,  发布年份 2016

来源: Springer

【 摘 要 】

Breast cancer (BC) is a serious disease to threat lives of women. Numerous studies have proved that BC originates from cancer stem cells (CSCs). But at present, no one approach can quickly and simply identify breast cancer stem cells (BCSCs) in solid tumor. Nanotechnology is probably able to realize this goal. But in study process, scientists find it seems that nanomaterials with one modality, such as magnetic resonance imaging (MRI) or fluorescence imaging (FI), have their own advantages and drawbacks. They cannot meet practical requirements in clinic. The nanoprobe combined MRI with FI modality is a promising tool to accurately detect desired cells with low amount in tissue. In this work, we briefly describe the MRI and FI development history, analyze advantages and disadvantages of nanomaterials with single modality in cancer cell detection. Then the application development of nanomaterials with dual-modality in cancer field is discussed. Finally, the obstacles and prospective of dual-modal nanoparticles in detection field of BCSCs are also pointed out in order to speed up clinical applications of nanoprobes.

【 授权许可】

CC BY   
© The Author(s) 2016