Study on expression of CDH4 in lung cancer

World Journal of Surgical Oncology

Research

Lisha Ying¹  Dan Su¹  Guangmao Yu²  Zhupeng Li²  Weimin Mao³ 

[1] Cancer Research Institute, Zhejiang Cancer Hospital, 38 Guangji Road, Hangzhou, Zhejiang, China;Department of Cardiothoracic Surgery, Shaoxing People’s Hospital, 568 Zhongxin Road, Shaoxing, Zhejiang, China;Department of Thoracic Surgery, Zhejiang Cancer Hospital, 38 Guangji Road, 310022, Hangzhou, Zhejiang, China;

关键词: CDH4;    Lung cancer;    Tumor suppressor gene;   

DOI  :  10.1186/s12957-016-1083-2

 received in 2016-06-30, accepted in 2016-12-22,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe human CDH4 gene, which encodes the R-cadherin protein, has an important role in cell migration and cell adhesion, sorting, tissue morphogenesis, and tumor genesis. This study analyzed the relationship of CDH4 mRNA expression with lung cancer.MethodsReal time PCR was applied to detect CDH4 mRNA transcription in 142 paired cases of lung cancer and noncancerous regions.ResultsNo correlation was identified between CDH4 mRNA expression and gender, age, lymphnode metastasis, TNM stage, family history, smoking state, drinking state (P > 0.05), but grade and histotype (P < 0.05). The relative CDH4 mRNA value was remarkably decreased in lung cancer tissues compared with noncancerous tissues (P = 0.001).ConclusionsWe found that CDH4 mRNA expression was associated with grade and histotype. What is more, the relative CDH4 mRNA value was decreased in the lung cancer tissues. Our results suggested that CDH4 might be a putative tumor suppressor gene (TSG) in lung cancer.

【 授权许可】

CC BY   
© The Author(s). 2017