Office and 24-hour heart rate and target organ damage in hypertensive patients

BMC Cardiovascular Disorders

Research Article

Luis García-Ortiz¹  José I Recio-Rodríguez¹  Manuel A Gómez-Marcos¹  Cristina Agudo-Conde¹  Ángel García-García¹  Emiliano Rodríguez-Sánchez¹  Maria C Patino-Alonso² 

[1] Primary Care Research Unit, La Alamedilla Health Center. REDIAPP. IBSAL.SACyL, Salamanca, Spain;Primary Care Research Unit, La Alamedilla Health Center. REDIAPP. IBSAL.SACyL, Salamanca, Spain;Statistics Department, University of Salamanca, Salamanca, Spain;

关键词: Heart rate;    Hypertension;    Blood pressure monitoring;    ambulatory;    Carotid arteries;    Hypertrophy;    left ventricular;    Kidney disease;   

DOI  :  10.1186/1471-2261-12-19

 received in 2011-11-25, accepted in 2012-03-22,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundWe investigated the association between heart rate and its variability with the parameters that assess vascular, renal and cardiac target organ damage.MethodsA cross-sectional study was performed including a consecutive sample of 360 hypertensive patients without heart rate lowering drugs (aged 56 ± 11 years, 64.2% male). Heart rate (HR) and its standard deviation (HRV) in clinical and 24-hour ambulatory monitoring were evaluated. Renal damage was assessed by glomerular filtration rate and albumin/creatinine ratio; vascular damage by carotid intima-media thickness and ankle/brachial index; and cardiac damage by the Cornell voltage-duration product and left ventricular mass index.ResultsThere was a positive correlation between ambulatory, but not clinical, heart rate and its standard deviation with glomerular filtration rate, and a negative correlation with carotid intima-media thickness, and night/day ratio of systolic and diastolic blood pressure. There was no correlation with albumin/creatinine ratio, ankle/brachial index, Cornell voltage-duration product or left ventricular mass index. In the multiple linear regression analysis, after adjusting for age, the association of glomerular filtration rate and intima-media thickness with ambulatory heart rate and its standard deviation was lost. According to the logistic regression analysis, the predictors of any target organ damage were age (OR = 1.034 and 1.033) and night/day systolic blood pressure ratio (OR = 1.425 and 1.512). Neither 24 HR nor 24 HRV reached statistical significance.ConclusionsHigh ambulatory heart rate and its variability, but not clinical HR, are associated with decreased carotid intima-media thickness and a higher glomerular filtration rate, although this is lost after adjusting for age.Trial RegistrationClinicalTrials.gov: NCT01325064

【 授权许可】

Unknown   
© García-García et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.