Prognostic value of HMGB1 overexpression in resectable gastric adenocarcinomas

World Journal of Surgical Oncology

Research

Huadong Zhao¹  Xianli He¹  Qing Qiao¹  Guoqiang Bao¹ 

[1] Department of general surgery, Tangdu Hospital, The Fourth Military Medical University, 710038, Xi'an, China;

关键词: Gastric Cancer;    Gastric Adenocarcinoma;    HMGB1 Protein;    Gastric Adenocarcinoma Cell;    HMGB1 Expression;   

DOI  :  10.1186/1477-7819-8-52

 received in 2010-02-21, accepted in 2010-06-26,  发布年份 2010

来源: Springer

【 摘 要 】

IntroductionHMGB1(High mobility group box 1), originally described as a nuclear protein, is now regarded as a multifunctional protein with a paradoxical dual effect in tumors. In the present study, HMGB1 overexpression and its correlation with the clinicopathologic characteristics and recurrence-free survival were evaluated in gastric adenocarcinomas.Methods76 gastric adenocarcinomas surgically removed entered the study. The immunohistochemical staining was used to assess HMGB1 expression through tissue microarray procedure. The clinicopathologic characteristics of all patients were recorded, and the regular follow-up was made for all patients.ResultsAlmost all the gastric adenocarcinomas showed HMGB1 positive staining mainly in the nucleus, and the overexpression of HMGB1 was found in cancerous tissues with higher strong reactivity rate, compared with non-cancerous tissues (total expression score ≥ 9, 42.0% vs. 9.0%, P < 0.001). Survival analysis revealed that tumor stage negatively correlated with cancer-free survival (P = 0.022). Furthermore, HMGB1 overexpression positively associated with cancer-free survival of resectable gastric adenocarcinomas (P = 0.023).ConclusionsThe overexpression of HMGB1 protein indicates that HMGB1 may play a role in the tumorigenesis of gastric adenocarcinomas. And the overexpression of HMGB1 may be a marker of good prognosis of gastric adenocarcinoma given curative resection combined with adjuvant chemotherapy.

【 授权许可】

Unknown   
© Bao et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.