Urine alkalization facilitates uric acid excretion

Nutrition Journal

Research

Aya Kanbara¹  Issei Seyama¹  Masayuki Hakoda² 

[1] Department of Nutrition and Health Promotion, Faculty for Human Development, Hiroshima Jyogakuin University, 4-13-1 Ushita-higashi Higashi-ku, 732-0063, Hiroshima, Japan;Department of Nutritional Sciences, Faculty of Human Ecology, Yasuda Women's University, 6-13-1 Yasuhigashi, Asaminami-ku, 731-0153, Hiroshima, Japan;

关键词: Uric Acid;    Gout;    Hyperuricemia;    Food Material;    Acid Diet;   

DOI  :  10.1186/1475-2891-9-45

 received in 2010-05-13, accepted in 2010-10-19,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundIncrease in the incidence of hyperuricemia associated with gout as well as hypertension, renal diseases and cardiovascular diseases has been a public health concern. We examined the possibility of facilitated excretion of uric acid by change in urine pH by managing food materials.MethodsWithin the framework of the Japanese government's health promotion program, we made recipes which consist of protein-rich and less vegetable-fruit food materials for H+-load (acid diet) and others composed of less protein but vegetable-fruit rich food materials (alkali diet). Healthy female students were enrolled in this consecutive 5-day study for each test. From whole-day collected urine, total volume, pH, organic acid, creatinine, uric acid and all cations (Na+,K+,Ca2+,Mg2+,NH4+) and anions (Cl-,SO42-,PO4-) necessary for the estimation of acid-base balance were measured.ResultsUrine pH reached a steady state 3 days after switching from ordinary daily diets to specified regimens. The amount of acid generated ([SO42-] +organic acid-gut alkai) were linearly related with those of the excretion of acid (titratable acidity+ [NH4+] - [HCO3-]), indicating that H+ in urine is generated by the metabolic degradation of food materials. Uric acid and excreted urine pH retained a linear relationship, where uric acid excretion increased from 302 mg/day at pH 5.9 to 413 mg/day at pH 6.5, despite the fact that the alkali diet contained a smaller purine load than the acid diet.ConclusionWe conclude that alkalization of urine by eating nutritionally well-designed food is effective for removing uric acid from the body.

【 授权许可】

Unknown   
© Kanbara et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.