Modeling amyloids in bacteria

Microbial Cell Factories

Commentary

Anna Villar-Piqué¹  Salvador Ventura² 

[1] Departament de Bioquímica i Biologia Molecular, Facultat de Biociències, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Spain;Departament de Bioquímica i Biologia Molecular, Facultat de Biociències, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Spain;Institut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Spain;

关键词: Fibril;    Amyloidosis;    Amyloid Fibril;    Amyloid Formation;    Yeast Prion;   

DOI  :  10.1186/1475-2859-11-166

 received in 2012-12-23, accepted in 2012-12-23,  发布年份 2012

来源: Springer

【 摘 要 】

An increasing number of proteins are being shown to assemble into amyloid structures, self-seeding fibrillar aggregates that may lead to pathological states or play essential biological functions in organisms. Bacterial cell factories have raised as privileged model systems to understand the mechanisms behind amyloid assembly and the cellular fitness cost associated to the formation of these aggregates. In the near future, these bacterial systems will allow implementing high-throughput screening approaches to identify effective modulators of amyloid aggregation.

【 授权许可】

CC BY   
© Villar-Pique and Ventura; licensee BioMed Central Ltd. 2012