The role of diabetes co-morbidity for tuberculosis treatment outcomes: a prospective cohort study from Mwanza, Tanzania

BMC Infectious Diseases

Research Article

Martine Grosos Aabye¹  Torben Martinussen²  Henrik Krarup³  Daniel Faurholt-Jepsen⁴  Henrik Friis⁴  Maria Faurholt-Jepsen⁴  Åse Bengård Andersen⁵  Dirk Lund Christensen⁶  Nyagosya Range⁷  George Praygod⁸  John Changalucha⁸  Jeremiah Kidola⁸  Daniel Rinse Witte⁹ 

[1] Clinical Research Centre, University of Copenhagen, Hvidovre Hospital, Hvidovre, Denmark;Department of Basic Sciences and Environment, University of Copenhagen, Frederiksberg, Denmark;Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark;Department of Human Nutrition, University of Copenhagen, Frederiksberg, Denmark;Department of Infectious Diseases, Odense University Hospital, Odense, Denmark;Department of International Health, University of Copenhagen, Copenhagen, Denmark;Steno Diabetes Center, Gentofte, Denmark;Muhimbili Medical Centre, National Institute of Medical Research, Dar Es Salaam, Tanzania;Mwanza Medical Centre, National Institute of Medical Research, Mwanza, Tanzania;Steno Diabetes Center, Gentofte, Denmark;

关键词: Tuberculosis;    Diabetes;    Treatment outcome;    Anthropometry;    Haemoglobin;    Grip strength;   

DOI  :  10.1186/1471-2334-12-165

 received in 2012-03-30, accepted in 2012-07-16,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundDue to the association between diabetes and pulmonary tuberculosis (TB), diabetes may threaten the control of TB. In a prospective cohort study nested in a nutrition trial, we investigated the role of diabetes on changes in anthropometry, grip strength, and clinical parameters over a five months follow-up period.MethodsAmong pulmonary TB patients with known diabetes status, we assessed anthropometry and clinical parameters (e.g. haemoglobin) at baseline and after two and five months of TB treatment. A linear mixed-effects model (repeated measurements) was used to investigate the role of diabetes during recovery.ResultsOf 1205 TB patients, the mean (standard deviation) age was 36.6 (13.0) years, 40.9% were females, 48.9% were HIV co-infected, and 16.3% had diabetes. TB patients with diabetes co-morbidity experienced a lower weight gain at two (1.3 kg, CI95% 0.5; 2.0, p = 0.001) and five months (1.0 kg, CI95% 0.3; 1.7, p = 0.007). Similarly, the increase in the level of haemoglobin was lower among TB patients with diabetes co-morbidity after two (Δ 0.6 g/dL, CI95% 0.3; 0.9 p < 0.001) and five months (Δ 0.5 g/dL, CI95% 0.2; 0.9 p = 0.004) of TB treatment, respectively.ConclusionTB patients initiating TB treatment with diabetes co-morbidity experience delayed recovery of body mass and haemoglobin, which are important for the functional recovery from disease.

【 授权许可】

CC BY   
© Faurholt-Jepsen et al.; licensee BioMed Central Ltd. 2012