Drug treatment for oral submucous fibrosis: an update

BMC Oral Health

Research

Hui Xie¹  Xueru Chen²  Jincai Guo³ 

[1] Department of Pharmacy, Changsha Stomatological Hospital, 410006, Changsha, China;School of Stomatology, Hunan University of Chinese Medicine, 410006, Changsha, China;Department of Pharmacy, Changsha Stomatological Hospital, 410006, Changsha, China;School of Stomatology, Hunan University of Chinese Medicine, 410006, Changsha, China;School of Pharmacy, Hunan University of Chinese Medicine, 410208, Changsha, China;Department of Pharmacy, Changsha Stomatological Hospital, 410006, Changsha, China;School of Stomatology, Hunan University of Chinese Medicine, 410006, Changsha, China;School of Pharmacy, Hunan University of Chinese Medicine, 410208, Changsha, China;Changsha Stomatological Hospital, No. 389 Youyi road, Tianxin district Changsha, Hunan, China;

关键词: Oral submucous fibrosis;    Drug treatment;    Clinical trials;   

DOI  :  10.1186/s12903-023-03488-9

 received in 2023-05-19, accepted in 2023-10-04,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectiveThe aim of this review is to evaluate the different medicinal interventions available for the management of oral submucous fibrosis (OSF).Materials and methodsWe conducted a comprehensive electronic search on PubMed, Web of Science, and Cochrane Library databases for articles related to OSF patients treated with medications from December 2011 to September 2022. GRADE system was used to evaluate the evidence quality. The reporting of the systematic review is in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. The main outcomes were the improvement of maximum mouth opening, burning sensation, cheek flexibility, and tongue protrusion.ResultsTwenty-nine randomized controlled trials (RCTs), five clinical trials (CCTs) were included, and the use of drugs for OSF treatment were evaluated. Drugs like steroids, hyaluronidase, pentoxifylline, lycopene, curcumin, dpirulina, aloe vera, omega3, oxitard, allicin, colchicine have been used. It was found that drugs with evidence high quality were salvia miltiorrhiza combined with triamcinolone acetonide, lycopene, pentoxifylline, curcumin, and aloe vera, and those with evidence moderate quality were allicin, colchicine, omega 3, and oxitard.ConclusionBased on the results of our comprehensive analysis, for long-term treatment, we found lycopene with low side effects, whereas for relieving the symptoms of severe burning sensation, aloe vera is the most effective. Although the recent review has made some progress, drug therapy for OSF remains unclear, and more high-quality RCTs are needed to identify better treatments for OSF.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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