Vascular complications and changes in body mass index in Japanese type 2 diabetic patients with abdominal obesity

Cardiovascular Diabetology

Original Investigation

Junji Kozawa¹  Tetsuhiro Kitamura¹  Norikazu Maeda¹  Tetsuyuki Yasuda¹  Hirofumi Nagao¹  Takekazu Kimura¹  Iichiro Shimomura¹  Hitoshi Nishizawa¹  Ayumu Hirata¹  Shiro Fukuda¹  Akihisa Imagawa¹  Kohei Okita¹  Tohru Funahashi²  Mamiko Tsugawa³  Takuya Okada³  Susumu Kashine⁴  Toshiyuki Hibuse⁴ 

[1] Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2-2 B-5, Yamada-oka, Suita, 565-0871, Osaka, Japan;Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, 2-2-B, Yamada-oka, Suita, 565-0871, Osaka, Japan;Ikeda Municipal Hospital, 3-1-18, Jonan, Ikeda, 563-8510, Osaka, Japan;Suita Municipal Hospital, 2-13-20, Katayamacho, Suita, 564-0082, Osaka, Japan;

关键词: Abdominal obesity;    Type 2 diabetes;    Waist circumference;    Visceral fat accumulation;    Body mass index;    Cardiovascular disease;   

DOI  :  10.1186/1475-2840-12-88

 received in 2013-04-30, accepted in 2013-06-13,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundAlthough many Asian type 2 diabetic patients have been considered to be not obese and have low capacity of insulin secretion, the proportion of obese patients with visceral fat accumulation has increased in recent years. We found previously considerable number of Japanese non-obese subjects (body mass index (BMI) < 25 kg/m2) with visceral fat accumulation and multiple cardiovascular risk factors. The aim of the study was to investigate the difference in clinical features of type 2 diabetic patients with and without visceral fat accumulation, focusing on vascular complications and changes in BMI.MethodsWe enrolled 88 Japanese hospitalized type 2 diabetic patients. Abdominal obesity represented waist circumference (WC) of ≥85 cm for males and ≥90 cm for females (corresponding to visceral fat area of 100 cm2). Subjects were divided into two groups; with or without abdominal obesity.ResultsHypertension, dyslipidemia and cardiovascular diseases were significantly more in the patients with abdominal obesity. The prevalence of cardiovascular disease in the non-obese patients (BMI < 25 kg/m2) with abdominal obesity were similar in obese patients (BMI ≥25 kg/m2). The mean BMI of the patients with abdominal obesity was < 25 kg/m2 at 20 years of age, but reached maximum to more than 30 kg/m2 in the course. Furthermore, substantial portion of the type 2 diabetic patients (52% in males and 43% in females) were not obese at 20 year-old (BMI < 25 kg/m2), but developed abdominal obesity by the time of admission.ConclusionThese results emphasize the need to control multiple risk factors and prevent atherosclerotic disease in patients with abdominal obesity. The significant weight gain after 20 years of age in patients with abdominal obesity stresses the importance of lifestyle modification in younger generation, to prevent potential development of type 2 diabetes and future atherosclerotic cardiovascular disease.

【 授权许可】

Unknown   
© Nagao et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.