Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission

Malaria Journal

Research

Peter M. Siba¹  Ivo Mueller²  Andrew Teo³  Holger W. Unger³  Wina Hasang⁴  Louise M. Randall⁴  Stephen J. Rogerson⁴  Graham V. Brown⁵ 

[1] Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea;The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia;Barcelona Centre for International Health Research (CRESIB), Barcelona, Spain;University of Melbourne, Department of Medicine (Royal Melbourne Hospital), Melbourne, VIC, Australia;University of Melbourne, Department of Medicine (Royal Melbourne Hospital), Melbourne, VIC, Australia;Victorian Infectious Diseases Service, The Doherty Institute, Melbourne, VIC, Australia;University of Melbourne, Department of Medicine (Royal Melbourne Hospital), Melbourne, VIC, Australia;Victorian Infectious Diseases Service, The Doherty Institute, Melbourne, VIC, Australia;The Nossal Institute for Global Health, The University of Melbourne, Melbourne, VIC, Australia;

关键词: Malaria;    Antibody;    Papua New Guinea;    Pregnancy;    Immunity;    Azithromycin;    Sulfadoxine-pyrimethamine;    Chloroquine;    IPTp;    ITN;   

DOI  :  10.1186/s12936-015-0736-x

 received in 2014-12-03, accepted in 2015-05-20,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundRegular anti-malarial therapy in pregnancy, a pillar of malaria control, may affect malaria immunity, with therapeutic implications in regions of reducing transmission.MethodsPlasma antibodies to leading vaccine candidate merozoite antigens and opsonizing antibodies to endothelial-binding and placental-binding infected erythrocytes were quantified in pregnant Melanesian women receiving sulfadoxine-pyrimethamine (SP) with chloroquine taken once, or three courses of SP with azithromycin.ResultsMalaria prevalence was low. Between enrolment and delivery, antibodies to recombinant antigens declined in both groups (p < 0.0001). In contrast, median levels of opsonizing antibodies did not change, although levels for some individuals changed significantly. In multivariate analysis, the malaria prevention regimen did not influence antibody levels.ConclusionDifferent preventive anti-malarial chemotherapy regimens used during pregnancy had limited impact on malarial-immunity in a low-transmission region of Papua New Guinea.Trial registrationsNCT01136850

【 授权许可】

CC BY   
© Teo et al.; licensee BioMed Central. 2015