Malaria Journal | |
Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission | |
Research | |
Peter M. Siba1  Ivo Mueller2  Andrew Teo3  Holger W. Unger3  Wina Hasang4  Louise M. Randall4  Stephen J. Rogerson4  Graham V. Brown5  | |
[1] Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea;The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia;Barcelona Centre for International Health Research (CRESIB), Barcelona, Spain;University of Melbourne, Department of Medicine (Royal Melbourne Hospital), Melbourne, VIC, Australia;University of Melbourne, Department of Medicine (Royal Melbourne Hospital), Melbourne, VIC, Australia;Victorian Infectious Diseases Service, The Doherty Institute, Melbourne, VIC, Australia;University of Melbourne, Department of Medicine (Royal Melbourne Hospital), Melbourne, VIC, Australia;Victorian Infectious Diseases Service, The Doherty Institute, Melbourne, VIC, Australia;The Nossal Institute for Global Health, The University of Melbourne, Melbourne, VIC, Australia; | |
关键词: Malaria; Antibody; Papua New Guinea; Pregnancy; Immunity; Azithromycin; Sulfadoxine-pyrimethamine; Chloroquine; IPTp; ITN; | |
DOI : 10.1186/s12936-015-0736-x | |
received in 2014-12-03, accepted in 2015-05-20, 发布年份 2015 | |
来源: Springer | |
【 摘 要 】
BackgroundRegular anti-malarial therapy in pregnancy, a pillar of malaria control, may affect malaria immunity, with therapeutic implications in regions of reducing transmission.MethodsPlasma antibodies to leading vaccine candidate merozoite antigens and opsonizing antibodies to endothelial-binding and placental-binding infected erythrocytes were quantified in pregnant Melanesian women receiving sulfadoxine-pyrimethamine (SP) with chloroquine taken once, or three courses of SP with azithromycin.ResultsMalaria prevalence was low. Between enrolment and delivery, antibodies to recombinant antigens declined in both groups (p < 0.0001). In contrast, median levels of opsonizing antibodies did not change, although levels for some individuals changed significantly. In multivariate analysis, the malaria prevention regimen did not influence antibody levels.ConclusionDifferent preventive anti-malarial chemotherapy regimens used during pregnancy had limited impact on malarial-immunity in a low-transmission region of Papua New Guinea.Trial registrationsNCT01136850
【 授权许可】
CC BY
© Teo et al.; licensee BioMed Central. 2015
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202311106976818ZK.pdf | 469KB | download |
【 参考文献 】
- [1]
- [2]
- [3]
- [4]
- [5]
- [6]
- [7]
- [8]
- [9]
- [10]
- [11]
- [12]
- [13]
- [14]
- [15]
- [16]