The validity and precision of the leicester cough questionnaire in COPD patients with chronic cough

Health and Quality of Life Outcomes

Research

Lisenka N Boom¹  Jan WK van den Berg¹  Nynke E ten Hertog¹  Farida F Berkhof¹  Steven M Uil¹  Huib AM Kerstjens² 

[1] department of pulmonary diseases, Isala klinieken, Zwolle, the Netherlands;department of pulmonary diseases, and University of Groningen, University Medical Center Groningen, Groningen, the Netherlands;

关键词: LCQ;    COPD;    validity;    cough;    health status;   

DOI  :  10.1186/1477-7525-10-4

 received in 2011-06-28, accepted in 2012-01-09,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundA validated instrument to assess the effects of chronic cough on health status in patients with chronic obstructive pulmonary disease (COPD) is currently not available. The Leicester Cough Questionnaire (LCQ) is a cough-specific health status questionnaire which is originally validated for a population of general patients presenting with chronic cough. We examined the psychometric performance of the LCQ in patients with COPD and chronic productive cough.MethodsConcurrent validity, internal consistency, reproducibility and responsiveness were determined. The St. George's Respiratory Questionnaire (SGRQ) and the Short Form-36 (SF-36) were used as external criteria. Questionnaires were completed at the start of the study. After 2 and 12 weeks the LCQ was repeated, together with a global rating of change.ResultsIn total 54 patients were included. Concurrent validity analysis showed significant correlations between corresponding domains of the LCQ and the SGRQ (rs -0.31 to -0.60). Corresponding domains of the LCQ and the SF-36 showed weaker correlations (rs 0.04 to 0.41). Internal consistency was adequate for two of the three domains (Cronbach's α 0.74 - 0.86). Test-retest reliability in stable patients was high (intraclass correlation coefficients 0.79 - 0.93). The mean difference after two weeks was 0.73 (± 1.75). Responsiveness analysis indicated that the LCQ was able to detect changes after 12 weeks.ConclusionThe LCQ is a valid, reliable, responsive instrument to measure health status in COPD patients with chronic productive cough.Trial RegistrationClinicalTrials.gov: NCT01071161

【 授权许可】

CC BY   
© Berkhof et al; licensee BioMed Central Ltd. 2012