Telocytes in the urinary system

Journal of Translational Medicine

Research

Duojiao Wu¹  Yonghua Zheng²  Xiangdong Wang³  Miao Lin⁴  Tongyu Zhu⁵ 

[1] Biomedical Research Center, Fudan University, Zhongshan Hospital, No.180, Fenglin Road, 200032, Shanghai, China;Department of Urology Surgery, Fudan University, Zhongshan Hospital, No.180, Fenglin Road, 200032, Shanghai, China;Department of Pulmonary Medicine, Fudan University, Zhongshan Hospital, No.180, Fenglin Road, 200032, Shanghai, China;Department of Pulmonary Medicine, Fudan University, Zhongshan Hospital, No.180, Fenglin Road, 200032, Shanghai, China;Biomedical Research Center, Fudan University, Zhongshan Hospital, No.180, Fenglin Road, 200032, Shanghai, China;Department of Urology Surgery, Fudan University, Zhongshan Hospital, No.180, Fenglin Road, 200032, Shanghai, China;Department of Urology Surgery, Fudan University, Zhongshan Hospital, No.180, Fenglin Road, 200032, Shanghai, China;Key Lab of Shanghai Organ Transplantation, Fudan University Zhongshan Hospital, No.180, Fenglin Road, 200032, Shanghai, China;

关键词: Telocytes;    Kidney;    Ureter;    Urinary bladder;   

DOI  :  10.1186/1479-5876-10-188

 received in 2012-05-13, accepted in 2012-09-06,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundTelocytes, a new type of interstitial cells, have been identified in many organs in mammals. The present studies aimed at investigating the ultrastructure, distribution and interactions of telocytes with surrounding cells in the urinary system of rats, to confirm the existence of telocytes in kidneys, ureter and urinary bladder.MethodsSamples of kidney, ureter, or urinary bladder were harvested for the ultrastructure by the electron microscope. The primary culture of telocytes was performed to investigate the dynamic alterations.ResultsTelocytes mainly located in the sub-capsular space of kidney, or between smooth muscle bundles and in the lamina propria of ureter and urinary bladder. Telocytes established numerous contacts with macrophages in the sub-capsular space of kidney, or with smooth muscle cells, nerve endings as well as blood capillaries in the ureter and urinary bladder. The complete morphology of telocytes with telopodes was observed clearly through the primary cell culture from the kidney tissues of rats.ConclusionsOur data evidenced the existence of telocytes in the urinary system, which may contribute to the tissue reparation and regeneration.

【 授权许可】

Unknown   
© Zheng et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.