A meta-analysis of the association between IL28B polymorphisms and infection susceptibility of hepatitis B virus in Asian population

BMC Gastroenterology

Research Article

Jing Chen¹  Xiaoguang Li¹  Wei Wang¹  Jie Xu¹ 

[1] Department of Infectious Disease, Peking University Third Hospital, 100191, Beijing, China;

关键词: Meta-analysis;    IL28B;    rs12979680;    rs8099917;    HBV;    Infection susceptibility;   

DOI  :  10.1186/s12876-015-0286-2

 received in 2015-01-05, accepted in 2015-04-24,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundSeveral association studies with small sample sizes of two SNPs in IL28BB (rs12979860 and rs8099917) showed inconsistent results, so in this study, we aim to evaluate the association between the two SNPs and infection susceptibility of Hepatitis B Virus (HBV) in Asian population, especially in Chinese population by meta-analysis.MethodsSearch the relevant published papers and perform meta-analysis respectively on IL28B (rs12979860 and rs8099917) in Asian population and Chinese population under an additive genetic model by STATA11.0.ResultsThe pooled odds ratios (OR) of rs12979860 are 0.79 (95% CI, 0.53-1.18; P = 0.25, I2 = 63.2%) and 1.62 (95% CI, 1.04-2.51; P = 0.033, I2 = 54.3%) respectively in Asian population and Chinese population analysis. The pooled OR of rs8099917 are 1.05 (95% CI, 0.93-1.19; P = 0.44, I2 = 43.3%) and 0.97 (95% CI, 0.84-1.23; P = 0.726, I2 = 15.6%) respectively in Asian population and Chinese population analysis.ConclusionOur study demonstrated that T allele of rs12979680 can increase the risk of HBV infection in Chinese population but not Asian population under an additive genetic model. There is no association between rs8099917 and HBV infection in Chinese population and Asian population.

【 授权许可】

Unknown   
© Chen et al. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.