Preparation, characterization, and biological activity of the inclusion complex of dihydroquercetin and β-Cyclodextrin

AAPS Open

Research

Weijun Chen¹  Yaping Xu¹  Qiuping Zhong¹  Ming Zhang¹  Tao Han¹  Wenxue Chen¹  Jianfei Pei¹  Haiming Chen²  Chujie Li³  Guido R. M. M. Haenen³  Yue Wang³  Mohamed Moalin⁴  Zhengwen Li⁵ 

[1] College of Food Science and Engineering, Hainan University, 58 Renmin Road, 570228, Haikou, Hainan, China;College of Food Science and Engineering, Hainan University, 58 Renmin Road, 570228, Haikou, Hainan, China;Maritime Academy, Hainan Vocational University of Science and Technology, 18 Qiongshan Road, 571126, Haikou, PR China;Department of Pharmacology and Personalized Medicine, School of Nutrition and Translational Research in Metabolism (NUTRIM); Cardiovascular Research Institute= Maastricht (CARIM), Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200, Maastricht, MD, the Netherlands;Research Centre Material Sciences, Zuyd University of Applied Science, 6400 AN, Heerlen, the Netherlands;School of Pharmacy, Chengdu University, 2025 Chengluo Avenue, 610106, Chengdu, Sichuan, China;

关键词: Dihydroquercetin;    β-cyclodextrin;    Complex;    Encapsulation;    Solubility;   

DOI  :  10.1186/s41120-023-00083-8

 received in 2023-03-14, accepted in 2023-08-29,  发布年份 2023

来源: Springer

【 摘 要 】

Dihydroquercetin (DHQ) is a natural occurring dihydroflavonol that has strong antioxidant and antibacterial activities. However, its application is limited due to its poor solubility. This study aims to improve the aqueous solubility of DHQ by complexing DHQ with β-cyclodextrin (β-CD) to boost its biological activity. DHQ was encapsulated with β-CD by freeze drying at a 1:1-M ratio. The structure of DHQ/β-CD complex prepared was elucidated by using Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction, scanning electron microscopy, and 1H nuclear magnetic resonance (1H NMR). In addition, molecular docking further revealed two energetically favorable conformations of the DHQ/β-CD complex, in which DHQ interacted with β-CD via hydrogen bonds. Experimental results showed that the solubility of the DHQ increased 22.63-fold by encapsulating with β-CD. Also the dissolution rate, antioxidant activity and antibacterial activity of the DHQ were significantly improved by encapsulating. The encapsulating with β-CD solves the problem of the poor aqueous solubility of DHQ, and broadens the path for a more optimal use of the health promoting effect of DHQ in pharmaceutical and food products.

【 授权许可】

CC BY   
© American Association of Pharmaceuticals Scientists 2023

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