Prevalent peripheral arterial disease and inflammatory burden

BMC Geriatrics

Research Article

Jane A. Cauley¹  Ahmed M. Kassem¹  Sara Thorson²  Nancy E. Lane³ 

[1] Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, A510 Crabtree Hall, 15261, Pittsburgh, PA, USA;Family Medicine of Southwest, Peacehealth Southwest Medical Center, 400 NE Mother Joseph Place, 986664, Vancouver, WA, USA;University of California Davis Health System, 4625 2nd Avenue, Suite 2006, 95817, Sacramento, CA, USA;

关键词: Peripheral arterial disease;    Peripheral vascular disease;    Inflammation;    Cytokine;    Ankle-arm index;    Ankle-brachial index;    Smoking;    Men;   

DOI  :  10.1186/s12877-016-0389-9

 received in 2016-03-01, accepted in 2016-12-06,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundStrong evidence implicates inflammation in the development of atherosclerotic heart disease but less is known about peripheral arterial disease (PAD). Our objective was to test the hypothesis that a composite index of inflammatory burden is associated with PAD.MethodsCross-sectional analysis of a randomly-selected group of 903 community-dwelling men in the MrOS cohort recruited between 2000 and 2002. Using blood samples, we measured seven cytokines and related these levels to prevalent PAD (ankle-brachial index (ABI) <0.9) both individually and as part of an “inflammatory burden score” (a composite sum of the number of pro-inflammatory cytokines in the highest quartile).ResultsOverall, 6.75% of men had ABI <0.9. The odds of prevalent PAD were higher in men with the highest quartile (Q4) levels of interleukin-6 multivariable (MV) adjusted (odds ratio (OR) =3.95 (95% CI, 1.4–11.3), tumor necrosis factor alpha OR = 4.44 (95% confidence interval (CI), 1.5–12.8), and C-reactive protein OR = 3.63 (95% CI, 1.4–9.4) compared to men in Q1. The magnitude of the association of these cytokines with PAD was similar to the effect of being 10 years older, OR = 2.41 (95% CI, 1.16–3.7). These significant effects persisted after additional MV adjustment for smoking except for CRP. Men with the highest inflammatory burden score (≥3) had 3.6 (95% CI, 1.5–8.7) increased odds of PAD, p trend = 0.03. After smoking adjustment the linear trend was borderline statistically significant (p trend = 0.10).ConclusionInflammatory burden is associated with prevalent PAD, an association similar to aging 10 years. The inflammatory effects of smoking contributes to the underlying association between inflammation and PAD.

【 授权许可】

CC BY   
© The Author(s). 2017