Demographic and clinical profiles of Plasmodium falciparum and Plasmodium vivax patients at a tertiary care centre in southwestern India

Malaria Journal

Research

Maria Bernabeu¹  Joseph D. Smith¹  Shripad Tuljapurkar²  Wenyun Zuo²  Kristen M. Skillman³  Usheer Kanjee³  Manoj T. Duraisingh³  Kathryn Shaw-Saliba³  Caeul Lim³  Devaraja G. Mudeppa⁴  Laura Chery⁴  Jennifer N. Maki⁴  John White⁴  Pradipsinh K. Rathod⁴  Shiva Kumar⁴  Jayashri T. Walke⁵  Anjali Mascarenhas⁵  Ambika Sharma⁵  Rimi Chakrabarti⁵  Rashmi Dash⁵  Riaz Basha Shaik⁵  Suresh Kumar Manoharan⁵  Anvily Almeida⁵  Mezia Fernandes⁵  Pooja Gawas⁵  Ligia Pereira⁵  Prasad Babar⁵  Diksha Shirodkar⁶  Roque G. W. Pinto⁶  Anar Khandeparkar⁶  Pradeep Naik⁶  Sunanda Amonkar⁶  V. N. Jindal⁶  Maria Silveria⁶  Edwin Gomes⁶  Nagesh Dubhashi⁶  Marina Vaz⁶  Rakesh Ramanan⁶  Neena Valecha⁷  Ashwani Kumar⁸ 

[1] Center for Infectious Disease Research (CIDR), 98109, Seattle, WA, USA;Department of Biology, Stanford University, 94305, Stanford, CA, USA;Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, 02115, Boston, MA, USA;Departments of Chemistry and Global Health, University of Washington, 98195, Seattle, WA, USA;Departments of Chemistry and Global Health, University of Washington, 98195, Seattle, WA, USA;Goa Medical College and Hospital, 403202, Bambolim, Goa, India;Goa Medical College and Hospital, 403202, Bambolim, Goa, India;National Institute of Malaria Research (ICMR), Sector 8, 110077, Dwarka, New Delhi, India;National Institute of Malaria Research, Field Unit, 403001, Campal, Goa, India;

关键词: MESA-ICEMR;    Goa;    Epidemiology;    Diagnostics;    Severity;    Characteristics;    Features;   

DOI  :  10.1186/s12936-016-1619-5

 received in 2016-08-12, accepted in 2016-11-15,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundMalaria remains an important cause of morbidity and mortality in India. Though many comprehensive studies have been carried out in Africa and Southeast Asia to characterize and examine determinants of Plasmodium falciparum and Plasmodium vivax malaria pathogenesis, fewer have been conducted in India.MethodsA prospective study of malaria-positive individuals was conducted at Goa Medical College and Hospital (GMC) from 2012 to 2015 to identify demographic, diagnostic and clinical indicators associated with P. falciparum and P. vivax infection on univariate analysis.ResultsBetween 2012 and 2015, 74,571 febrile individuals, 6287 (8.4%) of whom were malaria positive, presented to GMC. The total number of malaria cases at GMC increased more than two-fold over four years, with both P. vivax and P. falciparum cases present year-round. Some 1116 malaria-positive individuals (mean age = 27, 91% male), 88.2% of whom were born outside of Goa and 51% of whom were construction workers, were enroled in the study. Of 1088 confirmed malaria-positive patients, 77.0% had P. vivax, 21.0% had P. falciparum and 2.0% had mixed malaria. Patients over 40 years of age and with P. falciparum infection were significantly (p < 0.001) more likely to be hospitalised than younger and P. vivax patients, respectively. While approximately equal percentages of hospitalised P. falciparum (76.6%) and P. vivax (78.9%) cases presented with at least one WHO severity indicator, a greater percentage of P. falciparum inpatients presented with at least two (43.9%, p < 0.05) and at least three (29.9%, p < 0.01) severity features. There were six deaths among the 182 hospitalised malaria positive patients, all of whom had P. falciparum.ConclusionDuring the four year study period at GMC, the number of malaria cases increased substantially and the greatest burden of severe disease was contributed by P. falciparum.

【 授权许可】

CC BY   
© The Author(s) 2016