3D whole-heart phase sensitive inversion recovery CMR for simultaneous black-blood late gadolinium enhancement and bright-blood coronary CMR angiography

Journal of Cardiovascular Magnetic Resonance

Technical Notes

Giulia Ginami¹  Imran Rashid¹  Amedeo Chiribiri¹  Tevfik F. Ismail¹  Claudia Prieto²  René M. Botnar²  Radhouene Neji³ 

[1] School of Biomedical Engineering and Imaging Sciences, King’s College London, St Thomas’ Hospital (Lambeth Wing), Westminster Bridge Rd, SE1 7EH, London, UK;School of Biomedical Engineering and Imaging Sciences, King’s College London, St Thomas’ Hospital (Lambeth Wing), Westminster Bridge Rd, SE1 7EH, London, UK;Escuela de Ingeniería, Pontificia Universidad Católica de Chile, Vicuna Mackenna, 4860, Santiago, Chile;School of Biomedical Engineering and Imaging Sciences, King’s College London, St Thomas’ Hospital (Lambeth Wing), Westminster Bridge Rd, SE1 7EH, London, UK;MR Research Collaborations, Siemens Healthcare Limited, Sir William Siemens Square Frimley, GU16 8QD, Camberley, UK;

关键词: Whole-heart;    Black-blood;    Bright-blood;    Late gadolinium enhancement (LGE);    Coronary MR angiography;   

DOI  :  10.1186/s12968-017-0405-z

 received in 2017-08-23, accepted in 2017-11-06,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundPhase sensitive inversion recovery (PSIR) applied to late gadolinium enhancement (LGE) imaging is widely used in clinical practice. However, conventional 2D PSIR LGE sequences provide sub-optimal contrast between scar tissue and blood pool, rendering the detection of subendocardial infarcts and scar segmentation challenging. Furthermore, the acquisition of a low flip angle reference image doubles the acquisition time without providing any additional diagnostic information. The purpose of this study was to develop and test a novel 3D whole-heart PSIR-like framework, named BOOST, enabling simultaneous black-blood LGE assessment and bright-blood visualization of cardiac anatomy.MethodsThe proposed approach alternates the acquisition of a 3D volume preceded by a T2-prepared Inversion Recovery (T2Prep-IR) module (magnitude image) with the acquisition of a T2-prepared 3D volume (reference image). The two volumes (T2Prep-IR BOOST and bright-blood T2Prep BOOST) are combined in a PSIR-like reconstruction to obtain a complementary 3D black-blood volume for LGE assessment (PSIR BOOST). The black-blood PSIR BOOST and the bright-blood T2Prep BOOST datasets were compared to conventional clinical sequences for scar detection and coronary CMR angiography (CMRA) in 18 patients with a spectrum of cardiovascular disease (CVD).ResultsDatasets from 12 patients were quantitatively analysed. The black-blood PSIR BOOST dataset provided statistically improved contrast to noise ratio (CNR) between blood and scar when compared to a clinical 2D PSIR sequence (15.8 ± 3.3 and 4.1 ± 5.6, respectively). Overall agreement in LGE depiction was found between 3D black-blood PSIR BOOST and clinical 2D PSIR acquisitions, with 11/12 PSIR BOOST datasets considered diagnostic. The bright-blood T2Prep BOOST dataset provided high quality depiction of the proximal coronary segments, with improvement of visual score when compared to a clinical CMRA sequence. Acquisition time of BOOST (~10 min), providing information on both LGE uptake and heart anatomy, was comparable to that of a clinical single CMRA sequence.ConclusionsThe feasibility of BOOST for simultaneous black-blood LGE assessment and bright-blood coronary angiography was successfully tested in patients with cardiovascular disease. The framework enables free-breathing multi-contrast whole-heart acquisitions with 100% scan efficiency and predictable scan time. Complementary information on 3D LGE and heart anatomy are obtained reducing examination time.

【 授权许可】

CC BY   
© The Author(s). 2017