Effect of dietary supplementation on the prognostic value of urinary and serum 8-isoprostaglandin F2α in chemically-induced mammary carcinogenesis in the rat

Lipids in Health and Disease

Research

Sławomir Białek¹  Małgorzata Seweryn²  Barbara Bobrowska²  Andrzej Tokarz² 

[1] Department of Biochemistry and Clinical Chemistry, Medical University of Warsaw, 02-097, Poland, Banacha 1, Warsaw;Department of Bromatology, Medical University of Warsaw, 02-097, Poland, Banacha 1, Warsaw;

关键词: Resveratrol;    Genistein;    Standard Diet;    Polyphenolic Compound;    DMBA;   

DOI  :  10.1186/1476-511X-10-40

 received in 2011-01-28, accepted in 2011-03-03,  发布年份 2011

来源: Springer

【 摘 要 】

BackroundThe aim of the present study was to assess the effects of zinc or copper and polyphenolic compounds on the 8-isoprostaglandin F2α concentration in the serum and urine of rats with mammary cancer (adenocarcinoma) induced with 7,12-dimethylbenz[a]antracene. The research focused on the kinetics of alterations in urinary 8-isoPGF2α at the early stage of carcinogenesis as well as the influence of dietary factors on the process. The impact of selected compounds on the intensity of DMBA - induced carcinogenesis was also assessed.Result and conclusionsAdministration of DMBA, a compound that inducers mammary tumors in experimental animals, increased the serum and urinary 8-isoPGF2α levels in study rats. In the rat model, diet supplementation with zinc, combined with selected polyphenolic compounds (resveratrol or genistein) yielded a statistically significant decrease in the rat serum and urinary biomarker concentration with a simultaneously significant stimulation of carcinogenesis.The results indicate that there is an inverse correlation between the intensity of DMBA-induced carcinogenicity and the level of 8-isoPGF2α in urine and serum of rats.

【 授权许可】

CC BY   
© Bobrowska et al; licensee BioMed Central Ltd. 2011