The secret life of kinases: functions beyond catalysis

Cell Communication and Signaling

Review

David Romano¹  Jens Rauch¹  Natalia Volinsky¹  Walter Kolch² 

[1] Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland;Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland;Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland;

关键词: kinase;    kinase-independent;    non-catalytic;    ERBB;    EGFR;    Raf;    ERK;    Src;    PI3K;    AKT;    IGF;    Cell cycle;    PAK;    PDK;    FAK;    ASK;   

DOI  :  10.1186/1478-811X-9-23

 received in 2011-08-24, accepted in 2011-10-28,  发布年份 2011

来源: Springer

【 摘 要 】

Protein phosphorylation participates in the regulation of all fundamental biological processes, and protein kinases have been intensively studied. However, while the focus was on catalytic activities, accumulating evidence suggests that non-catalytic properties of protein kinases are essential, and in some cases even sufficient for their functions. These non-catalytic functions include the scaffolding of protein complexes, the competition for protein interactions, allosteric effects on other enzymes, subcellular targeting, and DNA binding. This rich repertoire often is used to coordinate phosphorylation events and enhance the specificity of substrate phosphorylation, but also can adopt functions that do not rely on kinase activity. Here, we discuss such kinase independent functions of protein and lipid kinases focussing on kinases that play a role in the regulation of cell proliferation, differentiation, apoptosis, and motility.

【 授权许可】

CC BY   
© Rauch et al; licensee BioMed Central Ltd. 2011