Clinical and virological factors associated with gastrointestinal symptoms in patients with acute respiratory infection: a two-year prospective study in general practice medicine

BMC Infectious Diseases

Research Article

Alessandra Falchi¹  Laetitia Minodier¹  Shirley Masse¹  Lisandru Capai¹  Thierry Blanchon²  Pierre-Emmanuel Ceccaldi³  Thomas Hanslik⁴  Sylvie van der Werf⁵  Remi Charrel⁶ 

[1] EA7310, Laboratoire de Virologie, Université de Corse-Inserm, 20250, Corte, France;Institut Pierre Louis d’Epidémiologie et de Santé Publique, Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, 56, Boulevard Vincent Auriol, 81393-75646, Paris, France;INSERM, UMR_S 1136, Institut Pierre Louis d’Epidémiologie et de Santé Publique, 56, Boulevard Vincent Auriol, 81393-75646, Paris, France;Pasteur Institute, Virology Department, Epidemiology and Physiopathology of Oncogenic Viruses Unit, F-75015, Paris, France;UMR CNRS 3569, 75015, Paris, France;Sorbonne Paris Cité, Cellule Pasteur, Université Paris Diderot, Institut Pasteur, 75015, Paris, France;Sorbonne Université, UPMC Université Paris 06, Institut Pierre-Louis d’Épidémiologie et de Santé Publique (IPLESP UMRS 1136), Paris, France;Hôpital Ambroise Paré, service de médecine interne, Boulogne-Billancourt, France;UFR des Sciences de la Santé Simone-Veil, Université Versailles Saint Quentin en Yvelines, Versailles, France;UMR CNRS 3569, 75015, Paris, France;Pasteur Institute, Virology Department, Molecular Genetics of RNA Viruses Unit, F-75015, Paris, France;Université Paris Diderot, Sorbonne Paris Cité, Unité de Génétique Moléculaire des Virus à ARN, EA302, F-75015, Paris, France;UMR “Emergence des Pathologies Virales” (EPV: Aix-Marseille Univ - IRD 190 - Inserm 1207 - EHESP) & Fondation IHU Méditerranée Infection, APHM Public Hospitals of Marseille, Marseille, France;

关键词: Acute respiratory infection;    Gastrointestinal symptoms;    Enteric pathogens;    Influenza virus;    General practitioner;   

DOI  :  10.1186/s12879-017-2823-9

 received in 2017-02-03, accepted in 2017-11-06,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundGastrointestinal (GI) symptoms, such as diarrhea, vomiting, abdominal pain and nausea are not an uncommon manifestation of an acute respiratory infection (ARI).We therefore evaluated clinical and microbiological factors associated with the presence of GI symptoms in patients consulting a general practitioner (GP) for ARI.MethodsNasopharyngeal swabs, stool specimens and clinical data from patients presenting to GPs with an ARI were prospectively collected during two winter seasons (2014-2016). Samples were tested by quantitative real-time PCR for 12 respiratory pathogen groups and for 12 enteric pathogens.ResultsTwo hundred and four of 331 included patients (61.6%) were positive for at least one respiratory pathogen. Sixty-nine stools (20.8%) were positive for at least one pathogen (respiratory and/or enteric). GI symptoms were more likely declared in case of laboratory confirmed-enteric infection (adjusted odds ratio (aOR) = 3.2; 95% confidence interval [CI] [1.2–9.9]; p = 0.02) or human coronavirus (HCoV) infection (aOR = 2.7; [1.2–6.8]; p = 0.02). Consumption of antipyretic medication before the consultation seemed to reduce the risk of developing GI symptoms for patients with laboratory-confirmed influenza (aOR = 0.3; [0.1–0.6]; p = 0.002).ConclusionsThe presence of GI symptoms in ARI patients could not be explained by the detection of respiratory pathogens in stools. However, the detection of enteric pathogens in stool samples could explained by the presence of GI symptoms in some of ARI cases. The biological mechanisms explaining the association between the presence of HCoVs in nasopharynx and GI symptoms need to be explored.

【 授权许可】

CC BY   
© The Author(s). 2017